Literature DB >> 24371068

Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus.

Benjamin J Burwitz1, Helen L Wu, Jason S Reed, Katherine B Hammond, Laura P Newman, Benjamin N Bimber, Francesca A Nimiyongskul, Enrique J Leon, Nicholas J Maness, Thomas C Friedrich, Masaru Yokoyama, Hironori Sato, Tetsuro Matano, David H O'Connor, Jonah B Sacha.   

Abstract

Compensatory mutations offset fitness defects resulting from CD8(+) T lymphocyte (CD8(TL))-mediated escape, but their impact on viral evolution following transmission to naive hosts remains unclear. Here, we investigated the reversion kinetics of Gag(181-189)CM9 CD8(TL) escape-associated compensatory mutations in simian immunodeficiency virus (SIV)-infected macaques. Preexisting compensatory mutations did not result in acute-phase escape of the SIVmac239 CD8(TL) epitope Gag(181-189)CM9 and instead required a tertiary mutation for stabilization in the absence of Gag(181-189)CM9 escape mutations. Therefore, transmitted compensatory mutations do not necessarily predict rapid CD8(TL) escape.

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Year:  2013        PMID： 24371068      PMCID： PMC3957937          DOI： 10.1128/JVI.03304-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts.

Authors:  Thomas C Friedrich; Adrian B McDermott; Matthew R Reynolds; Shari Piaskowski; Sarah Fuenger; Ivna P De Souza; Richard Rudersdorf; Candice Cullen; Levi J Yant; Lara Vojnov; Jason Stephany; Sarah Martin; David H O'Connor; Nancy Wilson; David I Watkins
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

2.  Reversion of CTL escape-variant immunodeficiency viruses in vivo.

Authors:  Thomas C Friedrich; Elizabeth J Dodds; Levi J Yant; Lara Vojnov; Richard Rudersdorf; Candice Cullen; David T Evans; Ronald C Desrosiers; Bianca R Mothé; John Sidney; Alessandro Sette; Kevin Kunstman; Steven Wolinsky; Michael Piatak; Jeffrey Lifson; Austin L Hughes; Nancy Wilson; David H O'Connor; David I Watkins
Journal:  Nat Med       Date:  2004-02-15       Impact factor: 53.440

3.  Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response.

Authors:  Thomas C Friedrich; Christopher A Frye; Levi J Yant; David H O'Connor; Nancy A Kriewaldt; Meghan Benson; Lara Vojnov; Elizabeth J Dodds; Candice Cullen; Richard Rudersdorf; Austin L Hughes; Nancy Wilson; David I Watkins
Journal:  J Virol       Date:  2004-03       Impact factor: 5.103

4.  Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication.

Authors:  Thomas C Friedrich; Laura E Valentine; Levi J Yant; Eva G Rakasz; Shari M Piaskowski; Jessica R Furlott; Kimberly L Weisgrau; Benjamin Burwitz; Gemma E May; Enrique J León; Taeko Soma; Gnankang Napoe; Saverio V Capuano; Nancy A Wilson; David I Watkins
Journal:  J Virol       Date:  2007-01-24       Impact factor: 5.103

5.  Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239.

Authors:  Nancy A Wilson; Jason Reed; Gnankang S Napoe; Shari Piaskowski; Andy Szymanski; Jessica Furlott; Edna J Gonzalez; Levi J Yant; Nicholas J Maness; Gemma E May; Taeko Soma; Matthew R Reynolds; Eva Rakasz; Richard Rudersdorf; Adrian B McDermott; David H O'Connor; Thomas C Friedrich; David B Allison; Amit Patki; Louis J Picker; Dennis R Burton; Jing Lin; Lingyi Huang; Deepa Patel; Gwendolyn Heindecker; Jiang Fan; Michael Citron; Melanie Horton; Fubao Wang; Xiaoping Liang; John W Shiver; Danilo R Casimiro; David I Watkins
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

6.  A dominant role for CD8+-T-lymphocyte selection in simian immunodeficiency virus sequence variation.

Authors:  David H O'Connor; Adrian B McDermott; Kendall C Krebs; Elizabeth J Dodds; Jacqueline E Miller; Edna J Gonzalez; Timothy J Jacoby; Levi Yant; Helen Piontkivska; Ralph Pantophlet; Dennis R Burton; William M Rehrauer; Nancy Wilson; Austin L Hughes; David I Watkins
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

7.  Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.

Authors:  Mark A Brockman; Arne Schneidewind; Matthew Lahaie; Aaron Schmidt; Toshiyuki Miura; Ivna Desouza; Faina Ryvkin; Cynthia A Derdeyn; Susan Allen; Eric Hunter; Joseph Mulenga; Paul A Goepfert; Bruce D Walker; Todd M Allen
Journal:  J Virol       Date:  2007-08-29       Impact factor: 5.103

8.  HIV evolution: CTL escape mutation and reversion after transmission.

Authors:  A J Leslie; K J Pfafferott; P Chetty; R Draenert; M M Addo; M Feeney; Y Tang; E C Holmes; T Allen; J G Prado; M Altfeld; C Brander; C Dixon; D Ramduth; P Jeena; S A Thomas; A St John; T A Roach; B Kupfer; G Luzzi; A Edwards; G Taylor; H Lyall; G Tudor-Williams; V Novelli; J Martinez-Picado; P Kiepiela; B D Walker; P J R Goulder
Journal:  Nat Med       Date:  2004-02-08       Impact factor: 53.440

9.  Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.

Authors:  Fred W Peyerl; Dan H Barouch; Wendy W Yeh; Heidi S Bazick; Jennifer Kunstman; Kevin J Kunstman; Steven M Wolinsky; Norman L Letvin
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

10.  Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.

Authors:  Arne Schneidewind; Mark A Brockman; Ruifeng Yang; Rahma I Adam; Bin Li; Sylvie Le Gall; Charles R Rinaldo; Sharon L Craggs; Rachel L Allgaier; Karen A Power; Thomas Kuntzen; Chang-Shung Tung; Montiago X LaBute; Sandra M Mueller; Thomas Harrer; Andrew J McMichael; Philip J R Goulder; Christopher Aiken; Christian Brander; Anthony D Kelleher; Todd M Allen
Journal:  J Virol       Date:  2007-09-05       Impact factor: 5.103
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