Literature DB >> 24370741

Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections.

Steve P Bernier1, Matthew L Workentine1, Michael G Surette1.   

Abstract

To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.

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Year:  2014        PMID： 24370741     DOI： 10.1038/ng.2859

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  Ecological succession in long-term experimentally evolved biofilms produces synergistic communities.

Authors:  Steffen R Poltak; Vaughn S Cooper
Journal:  ISME J       Date:  2010-09-02       Impact factor: 10.302

2.  Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.

Authors:  Inês N Silva; Ana S Ferreira; Jörg D Becker; James E A Zlosnik; David P Speert; Ji He; Dalila Mil-Homens; Leonilde M Moreira
Journal:  Microbiology       Date:  2011-08-11       Impact factor: 2.777

3.  Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections.

Authors:  Charles C Traverse; Leslie M Mayo-Smith; Steffen R Poltak; Vaughn S Cooper
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-27       Impact factor: 11.205

Review 4.  The changing microbial epidemiology in cystic fibrosis.

Authors:  John J Lipuma
Journal:  Clin Microbiol Rev       Date:  2010-04       Impact factor: 26.132

5.  Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing.

Authors:  J E Foweraker; C R Laughton; D F J Brown; D Bilton
Journal:  J Antimicrob Chemother       Date:  2005-05-09       Impact factor: 5.790

6.  Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections.

Authors:  Eilidh Mowat; Steve Paterson; Joanne L Fothergill; Elli A Wright; Martin J Ledson; Martin J Walshaw; Michael A Brockhurst; Craig Winstanley
Journal:  Am J Respir Crit Care Med       Date:  2011-02-04       Impact factor: 21.405

7.  Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia.

Authors:  Steve P Bernier; Pamela A Sokol
Journal:  J Bacteriol       Date:  2005-08       Impact factor: 3.490

8.  A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.

Authors:  Slade A Loutet; Ronald S Flannagan; Cora Kooi; Pamela A Sokol; Miguel A Valvano
Journal:  J Bacteriol       Date:  2006-03       Impact factor: 3.490

9.  Detecting SNPs and estimating allele frequencies in clonal bacterial populations by sequencing pooled DNA.

Authors:  Kathryn E Holt; Yik Y Teo; Heng Li; Satheesh Nair; Gordon Dougan; John Wain; Julian Parkhill
Journal:  Bioinformatics       Date:  2009-06-03       Impact factor: 6.937

10.  Phenotypic heterogeneity of Pseudomonas aeruginosa populations in a cystic fibrosis patient.

Authors:  Matthew L Workentine; Christopher D Sibley; Bryan Glezerson; Swathi Purighalla; Jens C Norgaard-Gron; Michael D Parkins; Harvey R Rabin; Michael G Surette
Journal:  PLoS One       Date:  2013-04-03       Impact factor: 3.240
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  2 in total

1.  In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host.

Authors:  A Launay; C-J Wu; A Dulanto Chiang; J-H Youn; P P Khil; J P Dekker
Journal:  Nat Commun       Date:  2021-07-23       Impact factor: 14.919

2.  The Flagellar Transcriptional Regulator FtcR Controls Brucella melitensis 16M Biofilm Formation via a betI-Mediated Pathway in Response to Hyperosmotic Stress.

Authors:  Jia Guo; Xingmei Deng; Yu Zhang; Shengnan Song; Tianyi Zhao; Dexin Zhu; Shuzhu Cao; Peter Ivanovic Baryshnikov; Gang Cao; Hugh T Blair; Chuangfu Chen; Xinli Gu; Liangbo Liu; Hui Zhang
Journal:  Int J Mol Sci       Date:  2022-08-31       Impact factor: 6.208
  2 in total

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