| Literature DB >> 24370374 |
Abstract
Aging is associated with a progressive decline in T cell function, chronic inflammation, hyperimmunoglobulinemia, autoimmunity, poor response to vaccines, and increased susceptibility to infection as well as diseases associated with chronic inflammation. DCs in aging appear to be functionally impaired with regard to response to uptake of antigens, phagocytosis of apoptotic cells, migration, priming of CD4+ and CD8+ T cells, and production of IFN-I and IFN-III. In this review I have discussed various mechanisms, which may be responsible for impaired functions of DCs.Entities:
Keywords: IFN-I; IFN-III; NF-κB; T cell priming; mDC; pDC
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Year: 2013 PMID： 24370374 DOI： 10.1016/j.exger.2013.12.009
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032