Literature DB >> 24369797

Designing clinical trials to address the needs of childhood and adult asthma: the National Heart, Lung, and Blood Institute's AsthmaNet.

E Rand Sutherland1, William W Busse2.   

Abstract

In 2008, the National Heart, Lung, and Blood Institute announced its intent to support a new asthma network known as AsthmaNet. This clinical trials consortium, now in its fifth year, has been charged with developing and executing clinical trials to address the most important asthma management questions and identify new treatment approaches in pediatric and adult patients. This review will discuss the organization of AsthmaNet and the scientific context in which the network was developed and began its work, report the results of an internal priority-setting exercise designed to guide the network's scientific strategy, and highlight the portfolio of clinical trials, proof-of-concept studies, and mechanistic studies planned for the 7-year period of the network to update the global asthma community regarding the progress and processes of the network.
Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Entities:  

Keywords:  APRIL; AVICA; Acetaminophen Vs. Ibuprofen in Children with Asthma; AsthmaNet; Azithromycin for Preventing the Development of Upper Respiratory Tract Illness into Lower Respiratory Tract Symptoms in Children; BADGER; BARD; Best Add-on Therapy Giving Effective Responses; Best African-American Response to Asthma Drugs; DCC; Data coordinating center; ICS; INFANT; Individualized Therapy for Asthma in Toddlers; Inhaled corticosteroid; NHLBI; NIH; National Heart, Lung, and Blood Institute; National Institutes of Health; OCELOT; Oral Corticosteroids for Treating Episodes of Significant Lower Respiratory Tract Symptoms in Children; PRC; Protocol Review Committee; RTI; Respiratory tract illness; SC; STICS; Steering Committee; Step-up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations; VIDA; Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma; asthma; asthma management; clinical trials; mechanistic studies; proof of concept; treatment

Mesh：

Substances：

Year:  2014        PMID： 24369797      PMCID： PMC3909925          DOI： 10.1016/j.jaci.2013.10.025

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   10.793


  29 in total

1.  Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma.

Authors:  Aaron Deykin; Michael E Wechsler; Homer A Boushey; Vernon M Chinchilli; Susan J Kunselman; Timothy J Craig; Emily DiMango; John V Fahy; Monica Kraft; Frank Leone; Stephen C Lazarus; Robert F Lemanske; Richard J Martin; Gene R Pesola; Stephen P Peters; Christine A Sorkness; Stanley J Szefler; Elliot Israel
Journal:  Am J Respir Crit Care Med       Date:  2006-09-14       Impact factor: 21.405

2.  beta-Adrenergic receptor polymorphisms and response to salmeterol.

Authors:  Michael E Wechsler; Erik Lehman; Stephen C Lazarus; Robert F Lemanske; Homer A Boushey; Aaron Deykin; John V Fahy; Christine A Sorkness; Vernon M Chinchilli; Timothy J Craig; Emily DiMango; Monica Kraft; Frank Leone; Richard J Martin; Stephen P Peters; Stanley J Szefler; Wenlei Liu; Elliot Israel
Journal:  Am J Respir Crit Care Med       Date:  2005-12-01       Impact factor: 21.405

3.  The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial.

Authors:  Richard J Martin; Stanley J Szefler; Tonya S King; Monica Kraft; Homer A Boushey; Vernon M Chinchilli; Timothy J Craig; Emily A Dimango; Aaron Deykin; John V Fahy; Elliot Israel; Stephen C Lazarus; Robert F Lemanske; Frank T Leone; Gene R Pesola; Stephen P Peters; Christine A Sorkness; Lisa A Szwejbka; Michael E Wechsler
Journal:  J Allergy Clin Immunol       Date:  2007-01       Impact factor: 10.793

4.  Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma.

Authors:  Stephen C Lazarus; Vernon M Chinchilli; Nancy J Rollings; Homer A Boushey; Reuben Cherniack; Timothy J Craig; Aaron Deykin; Emily DiMango; James E Fish; Jean G Ford; Elliot Israel; James Kiley; Monica Kraft; Robert F Lemanske; Frank T Leone; Richard J Martin; Gene R Pesola; Stephen P Peters; Christine A Sorkness; Stanley J Szefler; Michael E Wechsler; John V Fahy
Journal:  Am J Respir Crit Care Med       Date:  2007-01-04       Impact factor: 21.405

5.  Long-term inhaled corticosteroids in preschool children at high risk for asthma.

Authors:  Theresa W Guilbert; Wayne J Morgan; Robert S Zeiger; David T Mauger; Susan J Boehmer; Stanley J Szefler; Leonard B Bacharier; Robert F Lemanske; Robert C Strunk; David B Allen; Gordon R Bloomberg; Gregory Heldt; Marzena Krawiec; Gary Larsen; Andrew H Liu; Vernon M Chinchilli; Christine A Sorkness; Lynn M Taussig; Fernando D Martinez
Journal:  N Engl J Med       Date:  2006-05-11       Impact factor: 91.245

Review 6.  Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network.

Authors:  Loren C Denlinger; Christine A Sorkness; Vernon M Chinchilli; Robert F Lemanske
Journal:  J Allergy Clin Immunol       Date:  2006-12-04       Impact factor: 10.793

7.  Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study.

Authors:  Robert C Strunk; Leonard B Bacharier; Brenda R Phillips; Stanley J Szefler; Robert S Zeiger; Vernon M Chinchilli; Fernando D Martinez; Robert F Lemanske; Lynn M Taussig; David T Mauger; Wayne J Morgan; Christine A Sorkness; Ian M Paul; Theresa Guilbert; Marzena Krawiec; Ronina Covar; Gary Larsen
Journal:  J Allergy Clin Immunol       Date:  2008-10-25       Impact factor: 10.793

8.  The Pediatric Respiratory Assessment Measure: a valid clinical score for assessing acute asthma severity from toddlers to teenagers.

Authors:  Francine M Ducharme; Dominic Chalut; Laurie Plotnick; Cheryl Savdie; Denise Kudirka; Xun Zhang; Linyan Meng; David McGillivray
Journal:  J Pediatr       Date:  2007-10-31       Impact factor: 4.406

9.  Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial.

Authors:  Michael E Wechsler; Susan J Kunselman; Vernon M Chinchilli; Eugene Bleecker; Homer A Boushey; William J Calhoun; Bill T Ameredes; Mario Castro; Timothy J Craig; Loren Denlinger; John V Fahy; Nizar Jarjour; Shamsah Kazani; Sophia Kim; Monica Kraft; Stephen C Lazarus; Robert F Lemanske; Amy Markezich; Richard J Martin; Perdita Permaul; Stephen P Peters; Joe Ramsdell; Christine A Sorkness; E Rand Sutherland; Stanley J Szefler; Michael J Walter; Stephen I Wasserman; Elliot Israel
Journal:  Lancet       Date:  2009-11-21       Impact factor: 79.321

10.  Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing.

Authors:  Leonard B Bacharier; Brenda R Phillips; Robert S Zeiger; Stanley J Szefler; Fernando D Martinez; Robert F Lemanske; Christine A Sorkness; Gordon R Bloomberg; Wayne J Morgan; Ian M Paul; Theresa Guilbert; Marzena Krawiec; Ronina Covar; Gary Larsen; Michael Mellon; Mark H Moss; Vernon M Chinchilli; Lynn M Taussig; Robert C Strunk
Journal:  J Allergy Clin Immunol       Date:  2008-10-30       Impact factor: 10.793
View more
  10 in total

1.  Race is associated with differences in airway inflammation in patients with asthma.

Authors:  Sharmilee M Nyenhuis; Jerry A Krishnan; Alalia Berry; William J Calhoun; Vernon M Chinchilli; Linda Engle; Nicole Grossman; Fernando Holguin; Elliot Israel; Rick A Kittles; Monica Kraft; Stephen C Lazarus; Erik B Lehman; David T Mauger; James N Moy; Stephen P Peters; Wanda Phipatanakul; Lewis J Smith; Kaharu Sumino; Stanley J Szefler; Michael E Wechsler; Sally Wenzel; Steven R White; Steven J Ackerman
Journal:  J Allergy Clin Immunol       Date:  2017-01-06       Impact factor: 10.793

2.  IDeA States Pediatric Clinical Trials Network for Underserved and Rural Communities.

Authors:  Robert D Annett; Sheva Chervinskiy; Thomas H Chun; Kelly Cowan; Kristina Foster; Nathaniel Goodrich; Matthew Hirschfeld; Daniel S Hsia; J Dean Jarvis; Kurtis Kulbeth; Christi Madden; Clare Nesmith; Hengameh Raissy; Judith Ross; J Philip Saul; Bruce Shiramizu; Paul Smith; Janice E Sullivan; Lauren Tucker; Andrew M Atz
Journal:  Pediatrics       Date:  2020-09-17       Impact factor: 7.124

3.  Individualized therapy for persistent asthma in young children.

Authors:  Anne M Fitzpatrick; Daniel J Jackson; David T Mauger; Susan J Boehmer; Wanda Phipatanakul; William J Sheehan; James N Moy; Ian M Paul; Leonard B Bacharier; Michael D Cabana; Ronina Covar; Fernando Holguin; Robert F Lemanske; Fernando D Martinez; Jacqueline A Pongracic; Avraham Beigelman; Sachin N Baxi; Mindy Benson; Kathryn Blake; James F Chmiel; Cori L Daines; Michael O Daines; Jonathan M Gaffin; Deborah Ann Gentile; W Adam Gower; Elliot Israel; Harsha Vardhan Kumar; Jason E Lang; Stephen C Lazarus; John J Lima; Ngoc Ly; Jyothi Marbin; Wayne Morgan; Ross E Myers; J Tod Olin; Stephen P Peters; Hengameh H Raissy; Rachel G Robison; Kristie Ross; Christine A Sorkness; Shannon M Thyne; Stanley J Szefler
Journal:  J Allergy Clin Immunol       Date:  2016-10-21       Impact factor: 10.793

4.  NHLBI ASTHMA NETWORKS: IMPROVING PATIENT CARE, MOVING TOWARD PERSONALIZED MEDICINE.

Authors:  Stephen P Peters
Journal:  Trans Am Clin Climatol Assoc       Date:  2022

Review 5.  The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.

Authors:  Steve N Georas; Rosalind J Wright; Anastasia Ivanova; Elliot Israel; Lisa M LaVange; Praveen Akuthota; Tara F Carr; Loren C Denlinger; Merritt L Fajt; Rajesh Kumar; Wanda K O'Neal; Wanda Phipatanakul; Stanley J Szefler; Mark A Aronica; Leonard B Bacharier; Allison J Burbank; Mario Castro; Laura Crotty Alexander; Julie Bamdad; Juan Carlos Cardet; Suzy A A Comhair; Ronina A Covar; Emily A DiMango; Kim Erwin; Serpil C Erzurum; John V Fahy; Jonathan M Gaffin; Benjamin Gaston; Lynn B Gerald; Eric A Hoffman; Fernando Holguin; Daniel J Jackson; John James; Nizar N Jarjour; Nicholas J Kenyon; Sumita Khatri; John P Kirwan; Monica Kraft; Jerry A Krishnan; Andrew H Liu; Mark C Liu; M Alison Marquis; Fernando Martinez; Jacob Mey; Wendy C Moore; James N Moy; Victor E Ortega; David B Peden; Emily Pennington; Michael C Peters; Kristie Ross; Maria Sanchez; Lewis J Smith; Ronald L Sorkness; Michael E Wechsler; Sally E Wenzel; Steven R White; Joe Zein; Amir A Zeki; Patricia Noel
Journal:  J Allergy Clin Immunol       Date:  2021-11-29       Impact factor: 14.290

6.  Advances in pediatric asthma in 2013: coordinating asthma care.

Authors:  Stanley J Szefler
Journal:  J Allergy Clin Immunol       Date:  2014-03       Impact factor: 10.793

Review 7.  Researching asthma across the ages: insights from the National Heart, Lung, and Blood Institute's Asthma Network.

Authors:  Michael D Cabana; Susan J Kunselman; Sharmilee M Nyenhuis; Michael E Wechsler
Journal:  J Allergy Clin Immunol       Date:  2014-01       Impact factor: 10.793

8.  Vitamin D supplementation blocks pulmonary structural and functional changes in a rat model of perinatal vitamin D deficiency.

Authors:  Methap Yurt; Jie Liu; Reiko Sakurai; Ming Gong; Sumair M Husain; Mohammed A Siddiqui; Maleha Husain; Patricia Villarreal; Fatih Akcay; John S Torday; Virender K Rehan
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2014-10-10       Impact factor: 5.464

9.  Asthma Remission Disparities Among US Youth by Sexual Identity and Race/Ethnicity, 2009-2017.

Authors:  Caleb W Curry; Dylan Felt; Kristin Kan; Megan Ruprecht; Xinzi Wang; Gregory Phillips; Lauren B Beach
Journal:  J Allergy Clin Immunol Pract       Date:  2021-05-05

10.  Recommendations and evidence for reporting items in pediatric clinical trial protocols and reports: two systematic reviews.

Authors:  April V P Clyburne-Sherin; Pravheen Thurairajah; Mufiza Z Kapadia; Margaret Sampson; Winnie W Y Chan; Martin Offringa
Journal:  Trials       Date:  2015-09-18       Impact factor: 2.279
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.