| Literature DB >> 2436944 |
T Kurosaki, K Fukuda, T Konno, Y Mori, K Tanaka, M Mishina, S Numa.
Abstract
The four kinds of subunits of the Torpedo californica nicotinic acetylcholine receptor have been produced in various combinations by injecting Xenopus oocytes with the corresponding subunit-specific mRNAs synthesized by transcription in vitro of the cloned cDNAs. Functional analysis suggests that association of the alpha-subunit with either the gamma- or the delta-subunit is a prerequisite for generating the conformation necessary for agonist binding. The acetylcholine receptor devoid of either the beta-, gamma- or delta-subunit exhibits weak channel activity.Entities:
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Year: 1987 PMID： 2436944 DOI： 10.1016/0014-5793(87)80065-0
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124