Deng Ke-Wu1, Shi Xu-Bo2, Zhao Ying-Xin3, Yang Shi-Wei3, Zhou Yu-Jie4, Shi Dong-Mei3, Liu Yu-Yang3, Jia De-An3, Fang Zhe3, Zhou Zhi-Ming3, Ge Hai-Long3, Yan Zhen-Xian3, Ma Chang-Sheng1. 1. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 2. Department of Cardiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 3. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 4. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China azzyj12@163.com.
Abstract
OBJECTIVE: To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI). METHOD: Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3. RESULTS:Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively). CONCLUSION:Exogenous CP was helpful to reduce myocardial injury after PCI.
RCT Entities:
OBJECTIVE: To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI). METHOD: Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3. RESULTS: Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively). CONCLUSION: Exogenous CP was helpful to reduce myocardial injury after PCI.