Literature DB >> 24365954

Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy.

Kimberley S Samkoe1, Amber Bryant2, Jason R Gunn2, Stephen P Pereira3, Tayyaba Hasan4, Brian W Pogue1.   

Abstract

The use of in vivo contrast-enhanced magnetic resonance (MR) imaging as a surrogate for photosensitizer (verteporfin) dosimetry in photodynamic therapy of pancreas cancer is demonstrated by correlating MR contrast uptake to ex vivo fluorescence images on excised tissue. An orthotopic pancreatic xenograft mouse model was used for the study. A strong correlation (r = 0.57) was found for bulk intensity measurements of T1-weighted gadolinium enhancement and verteporfin fluorescence in the tumor region of interest. The use of contrast-enhanced MR imaging shows promise as a method for treatment planning and photosensitizer dosimetry in human photodynamic therapy (PDT) of pancreas cancer.

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Year:  2013        PMID： 24365954      PMCID： PMC3870269          DOI： 10.1117/1.JBO.18.12.120504

Source DB:  PubMed          Journal:  J Biomed Opt        ISSN： 1083-3668            Impact factor:   3.170


  7 in total

1.  A methodology for registration of a histological slide and in vivo MRI volume based on optimizing mutual information.

Authors:  Charles R Meyer; Bradford A Moffat; Kyle K Kuszpit; Peyton L Bland; Paul E Mckeever; Timothy D Johnson; Thomas L Chenevert; Alnawaz Rehemtulla; Brian D Ross
Journal:  Mol Imaging       Date:  2006 Jan-Mar       Impact factor: 4.488

2.  Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue.

Authors:  Scott C Davis; Brian W Pogue; Roger Springett; Christoph Leussler; Peter Mazurkewitz; Stephen B Tuttle; Summer L Gibbs-Strauss; Shudong S Jiang; Hamid Dehghani; Keith D Paulsen
Journal:  Rev Sci Instrum       Date:  2008-06       Impact factor: 1.523

3.  Clinical pharmacokinetics of verteporfin.

Authors:  Jean-Marie Houle; Andrew Strong
Journal:  J Clin Pharmacol       Date:  2002-05       Impact factor: 3.126

4.  Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models.

Authors:  Kimberley S Samkoe; Alina Chen; Imran Rizvi; Julia A O'Hara; P Jack Hoopes; Stephen P Pereira; Tayyaba Hasan; Brian W Pogue
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-01-01       Impact factor: 7.038

5.  Analysis of effective molecular diffusion rates for verteporfin in subcutaneous versus orthotopic Dunning prostate tumors.

Authors:  Xiaodong Zhou; Brian W Pogue; Bin Chen; Tayyaba Hasan
Journal:  Photochem Photobiol       Date:  2004-04       Impact factor: 3.421

6.  Registering histologic and MR images of prostate for image-based cancer detection.

Authors:  Yiqiang Zhan; Yangming Ou; Michael Feldman; John Tomaszeweski; Christos Davatzikos; Dinggang Shen
Journal:  Acad Radiol       Date:  2007-11       Impact factor: 3.173

7.  Facilitating tumor functional assessment by spatially relating 3D tumor histology and in vivo MRI: image registration approach.

Authors:  Lejla Alic; Joost C Haeck; Karin Bol; Stefan Klein; Sandra T van Tiel; Piotr A Wielepolski; Marion de Jong; Wiro J Niessen; Monique Bernsen; Jifke F Veenland
Journal:  PLoS One       Date:  2011-08-29       Impact factor: 3.240
  7 in total
  1 in total

1.  Perfusion CT estimates photosensitizer uptake and biodistribution in a rabbit orthotopic pancreatic cancer model: a pilot study.

Authors:  Jonathan T Elliott; Kimberley S Samkoe; Jason R Gunn; Errol E Stewart; Timothy B Gardner; Kenneth M Tichauer; Ting-Yim Lee; P Jack Hoopes; Stephen P Pereira; Tayyaba Hasan; Brian W Pogue
Journal:  Acad Radiol       Date:  2015-02-14       Impact factor: 3.173
  1 in total

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