Experimental studies on the influence of fibrin adhesive, factor XIII, and calcitonin on the incorporation and remodeling of autologous bone grafts.

In an experimental study on sheep the effects of fibrin adhesive system (FAS), plasma factor XIII (FXIII), and calcitonin on autologous cancellous bone grafts were studied. Drill holes in the tibia were filled with transplant bone, either untreated or locally treated with fibrin adhesive, with or without plasma factor XIII. We used 24 sheep, divided into three groups. Plasma factor XIII and calcitonin were administered parenterally; the third group received no treatment. For evaluation we carried out quantitative bone and fluorescence morphometry and microangiography. We found that local fibrin adhesive significantly decreased the remodeling and growth of the transplanted cancellous bone. Plasma factor XIII, given parenterally, increased the amount of bone in the transplant site; calcitonin showed no visible effect.