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Literature DB >> 24365855

Bidirectional conversion of intestinal epithelial cells: NFκB is key.

Abstract

NFκB represents a key transcription factor within the inflammatory tumor microenvironment; however, NFκB's function in tumor-initiating cells has not been examined yet. A recent Cell paper by Schwitalla et al. reports that NFκB modulates Wnt signaling and shows that enhanced Wnt activation induces dedifferentiation of nonstem cells that acquire tumor-initiating capacity.

Entities: Disease Gene

Keywords: EMT; Lgr5; NFκB; Wnt signaling; chronic inflammation; dedifferentiation; microenvironment

Mesh：

Year: 2014 PMID： 24365855 PMCID： PMC3928131 DOI： 10.4161/cbt.27629

Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742

13 in total

1. Inflammation 2010: new adventures of an old flame.

Authors: Ruslan Medzhitov
Journal: Cell Date: 2010-03-19 Impact factor: 41.582

Review 2. Immunity, inflammation, and cancer.

Authors: Sergei I Grivennikov; Florian R Greten; Michael Karin
Journal: Cell Date: 2010-03-19 Impact factor: 41.582

3. Cancer stem cells: Here, there, everywhere?

Authors: Connie J Eaves
Journal: Nature Date: 2008-12-04 Impact factor: 49.962

4. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Authors: Toshiro Sato; Robert G Vries; Hugo J Snippert; Marc van de Wetering; Nick Barker; Daniel E Stange; Johan H van Es; Arie Abo; Pekka Kujala; Peter J Peters; Hans Clevers
Journal: Nature Date: 2009-03-29 Impact factor: 49.962

5. Top-down morphogenesis of colorectal tumors.

Authors: I M Shih; T L Wang; G Traverso; K Romans; S R Hamilton; S Ben-Sasson; K W Kinzler; B Vogelstein
Journal: Proc Natl Acad Sci U S A Date: 2001-02-20 Impact factor: 11.205

6. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.

Authors: Sean L Preston; Wai-Man Wong; Annie On-On Chan; Richard Poulsom; Rosemary Jeffery; Robert A Goodlad; Nikki Mandir; George Elia; Marco Novelli; Walter F Bodmer; Ian P Tomlinson; Nicholas A Wright
Journal: Cancer Res Date: 2003-07-01 Impact factor: 12.701

Bidirectional conversion of intestinal epithelial cells: NFκB is key.

1. Inflammation 2010: new adventures of an old flame.

Review 2. Immunity, inflammation, and cancer.

3. Cancer stem cells: Here, there, everywhere?

4. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

5. Top-down morphogenesis of colorectal tumors.

6. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.

7. Crypt stem cells as the cells-of-origin of intestinal cancer.

Review 8. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.

9. Identification of stem cells in small intestine and colon by marker gene Lgr5.

Review 10. Hallmarks of cancer: the next generation.

1. An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.