Literature DB >> 24364511

Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO.

Hannah Baars1, Astrid Beyer, Stefanie V Kohlhepp, Carsten Bolm.   

Abstract

Benzimidazoles are prepared by intramolecular N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 °C. In this manner, diversely substituted products have been obtained in moderate to very good yields.

Entities:  

Year:  2013        PMID： 24364511     DOI： 10.1021/ol403414v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: a three-component one-pot tandem procedure.

Authors:  Christina L Magyar; Tyler J Wall; Steven B Davies; Molly V Campbell; Haven A Barna; Sydney R Smith; Christopher J Savich; R Adam Mosey
Journal:  Org Biomol Chem       Date:  2019-08-28       Impact factor: 3.876

2.  Enantioselective C2-Allylation of Benzimidazoles Using 1,3-Diene Pronucleophiles.

Authors:  James Levi Knippel; Yuxuan Ye; Stephen L Buchwald
Journal:  Org Lett       Date:  2021-03-01       Impact factor: 6.005

3.  Base-Mediated One-Pot Synthesis of Aliphatic Diazirines for Photoaffinity Labeling.

Authors:  Lei Wang; Zetryana Puteri Tachrim; Natsumi Kurokawa; Fumina Ohashi; Yasuko Sakihama; Yasuyuki Hashidoko; Makoto Hashimoto
Journal:  Molecules       Date:  2017-08-22       Impact factor: 4.411

4.  The selective synthesis of N-arylbenzene-1,2-diamines or 1-arylbenzimidazoles by irradiating 4-methoxy-4'-substituted-azobenzenes in different solvents.

Authors:  Po-Yi Chen; Chi-Wei Hsu; Tong-Ing Ho; Jinn-Hsuan Ho
Journal:  RSC Adv       Date:  2021-02-10       Impact factor: 3.361

5.  An improved synthesis of telmisartan via the copper-catalyzed cyclization of o-haloarylamidines.

Authors:  Junchi Zhang; Rui Li; Fuqiang Zhu; Changliang Sun; Jingshan Shen
Journal:  RSC Adv       Date:  2020-04-03       Impact factor: 3.361

Review 6.  Advances in the Synthesis of Ring-Fused Benzimidazoles and Imidazobenzimidazoles.

Authors:  Martin Sweeney; Darren Conboy; Styliana I Mirallai; Fawaz Aldabbagh
Journal:  Molecules       Date:  2021-05-04       Impact factor: 4.411
  6 in total

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