Literature DB >> 24363509

Helicobacter pylori and interleukin-8 in gastric cancer.

Ko Eun Lee1, Pham Ngoc Khoi1, Yong Xia1, Jung Sun Park1, Young Eun Joo1, Kyung Keun Kim1, Seok Yong Choi1, Young Do Jung1.   

Abstract

Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer.
© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.

Entities:  

Keywords:  Gastric cancer; Helicobacter pylori; Interleukin-8; Signals; Therapeutics

Mesh：

Substances：

Year:  2013        PMID： 24363509      PMCID： PMC3857441          DOI： 10.3748/wjg.v19.i45.8192

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  120 in total

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