Literature DB >> 2436258

Involvement of neuronal chloride channels in ethanol intoxication, tolerance, and dependence.

A M Allan, R A Harris.   

Abstract

Studies of the role of neuronal chloride channels in ethanol action have focused on chloride channels coupled to gamma-aminobutyric acid (GABA) receptors. Ethanol intoxication is hypothesized to result from enhancement of GABA action, leading to increased chloride conductance and decreased neuronal excitability. Chronic ethanol treatment is suggested to produce a subsensitivity to GABA, leading to decreased action of ethanol and hyperexcitability on withdrawal of ethanol. Behavioral, electrophysiological, and biochemical studies of acute and chronic ethanol treatments on the GABA-regulated chloride channels of brain are reviewed.

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Year:  1987        PMID： 2436258     DOI： 10.1007/978-1-4899-1684-6_12

Source DB:  PubMed          Journal:  Recent Dev Alcohol        ISSN： 0738-422X


  11 in total

1.  GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption.

Authors:  Aki Takahashi; Carolyn Kwa; Joseph F Debold; Klaus A Miczek
Journal:  Psychopharmacology (Berl)       Date:  2010-06-30       Impact factor: 4.530

2.  The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder.

Authors:  David J Rossi; Ben D Richardson
Journal:  Handb Exp Pharmacol       Date:  2018

Review 3.  GABAergic mechanisms in the electrophysiological actions of ethanol on cerebellar neurons.

Authors:  M R Palmer; B J Hoffer
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

4.  Limited access to ethanol increases the number of spontaneously active dopamine neurons in the posterior ventral tegmental area of nondependent P rats.

Authors:  Sandra L Morzorati; Rita L Marunde; David Downey
Journal:  Alcohol       Date:  2010-05       Impact factor: 2.405

5.  Ethanol-induced locomotor sensitization in DBA/2J mice is associated with alterations in GABA(A) subunit gene expression and behavioral sensitivity to GABA(A) acting drugs.

Authors:  David N Linsenbardt; Stephen L Boehm
Journal:  Pharmacol Biochem Behav       Date:  2010-02-26       Impact factor: 3.533

6.  Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligands.

Authors:  Darin J Knapp; David H Overstreet; George R Breese
Journal:  Alcohol Clin Exp Res       Date:  2005-04       Impact factor: 3.455

7.  Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area.

Authors:  B S Givens; G R Breese
Journal:  J Pharmacol Exp Ther       Date:  1990-08       Impact factor: 4.030

Review 8.  GABAA receptor subtypes: the "one glass of wine" receptors.

Authors:  Richard W Olsen; Harry J Hanchar; Pratap Meera; Martin Wallner
Journal:  Alcohol       Date:  2007-05       Impact factor: 2.405

9.  Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans.

Authors:  M Wallner; H J Hanchar; R W Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-18       Impact factor: 11.205

10.  Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence.

Authors:  Mary W Hulin; Russell J Amato; Johnny R Porter; Catalin M Filipeanu; Peter J Winsauer
Journal:  Adv Pharmacol Sci       Date:  2011-10-31
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