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Literature DB >> 24362027

Stem cells and stem cell-derived tissues and their use in safety assessment.

Abstract

Toxicology has long relied on animal models in a tedious approach to understanding risk of exposure to an uncharacterized molecule. Stem cell-derived tissues can be made in high purity, quality, and quantity to enable a new approach to this problem. Currently, stem cell-derived tissues are primarily "generic" genetic backgrounds; the future will see the integration of various genetic backgrounds and complex three-dimensional models to create truly unique in vitro organoids. This minireview focuses on the state of the art of a number of stem cell-derived tissues and details their application in toxicology.

Keywords: Cardiovascular; Drug Development; Drug Discovery; Embryonic Stem Cell; Hepatocyte; Induced Pluripotent Stem Cells; Neurons; Stem Cells; Toxicology

Mesh：

Year: 2013 PMID： 24362027 PMCID： PMC3931016 DOI： 10.1074/jbc.R113.481028

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

67 in total

1. Juvenile animal studies: testing strategies and design.

Authors: M E Hurtt; G Daston; K Davis-Bruno; M Feuston; B Silva Lima; S Makris; M E McNerney; J D Sandler; K Whitby; P Wier; G D Cappon
Journal: Birth Defects Res B Dev Reprod Toxicol Date: 2004-08

2. Differentiation of mouse and human embryonic stem cells into hepatic lineages.

Authors: Nobuaki Shiraki; Kahoko Umeda; Naomi Sakashita; Motohiro Takeya; Kazuhiko Kume; Shoen Kume
Journal: Genes Cells Date: 2008-05-30 Impact factor: 1.891

3. Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs.

Authors: Tomomi G Otsuji; Itsunari Minami; Yuko Kurose; Kaori Yamauchi; Masako Tada; Norio Nakatsuji
Journal: Stem Cell Res Date: 2010-02-06 Impact factor: 2.020

4. A high-throughput screen for teratogens using human pluripotent stem cells.

Authors: Sei Kameoka; Joshua Babiarz; Kyle Kolaja; Eric Chiao
Journal: Toxicol Sci Date: 2013-10-23 Impact factor: 4.849

5. Prevalidation of the Embryonic Stem Cell Test (EST)-A New In Vitro Embryotoxicity Test.

Authors: G Scholz; E Genschow; I Pohl; S Bremer; M Paparella; H Raabe; J Southee; H Spielmann
Journal: Toxicol In Vitro Date: 1999 Aug-Oct Impact factor: 3.500

Review 6. Isolated heart perfusion according to Langendorff---still viable in the new millennium.

Authors: Monika Skrzypiec-Spring; Bartosz Grotthus; Adam Szelag; Richard Schulz
Journal: J Pharmacol Toxicol Methods Date: 2006-05-26 Impact factor: 1.950

7. Application of three-dimensional culture conditions to human embryonic stem cell-derived definitive endoderm cells enhances hepatocyte differentiation and functionality.

Authors: Thamil Selvee Ramasamy; Jason S L Yu; Clare Selden; Humphery Hodgson; Wei Cui
Journal: Tissue Eng Part A Date: 2012-09-24 Impact factor: 3.845

8. [Improving the embryonic stem cell test (EST) by establishing molecular endpoints of tissue specific development using murine embryonic stem cells (D3 cells)].

Authors: Andrea Seiler; Anke Visan; Ingeborg Pohl; Elke Genschow; Roland Buesen; Horst Spielmann
Journal: ALTEX Date: 2002 Impact factor: 6.043

9. In vitro assessment of developmental neurotoxicity: use of microelectrode arrays to measure functional changes in neuronal network ontogeny.

Authors: Brian L Robinette; Joshua A Harrill; William R Mundy; Timothy J Shafer
Journal: Front Neuroeng Date: 2011-01-20

10. Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.

Authors: Yi Han; Aaron Miller; Julie Mangada; Ying Liu; Andrzej Swistowski; Ming Zhan; Mahendra S Rao; Xianmin Zeng
Journal: PLoS One Date: 2009-09-23 Impact factor: 3.240

9 in total

Review 1. Cell death assays for neurodegenerative disease drug discovery.

Authors: Jeremy W Linsley; Terry Reisine; Steven Finkbeiner
Journal: Expert Opin Drug Discov Date: 2019-06-10 Impact factor: 6.098

2. High-Content Assay Multiplexing for Muscle Toxicity Screening in Human-Induced Pluripotent Stem Cell-Derived Skeletal Myoblasts.

Authors: William D Klaren; Ivan Rusyn
Journal: Assay Drug Dev Technol Date: 2018-08-02 Impact factor: 1.738

3. Introduction to thematic minireview series: Development of human therapeutics based on induced pluripotent stem cell (iPSC) technology.

Authors: Mahendra Rao; Joel M Gottesfeld
Journal: J Biol Chem Date: 2013-12-20 Impact factor: 5.157

4. Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants.

Authors: Lisa Hoelting; Stefanie Klima; Christiaan Karreman; Marianna Grinberg; Johannes Meisig; Margit Henry; Tamara Rotshteyn; Jörg Rahnenführer; Nils Blüthgen; Agapios Sachinidis; Tanja Waldmann; Marcel Leist
Journal: Stem Cells Transl Med Date: 2016-03-01 Impact factor: 6.940