BACKGROUND: Many articles have shown that HIV infection can modify the clinical course of leprosy, but very scant epidemiological and clinical data about this co-infection are available in the peer-reviewed literature. METHODS: We herein describe the geographical distribution and demographic characteristics of 92 HIV/Mycobacterium leprae co-infected patients assisted in a Brazilian Leprosy referral center. A multivariate analysis was performed in order to establish clinical factors associated with type 1 reaction. RESULTS: Co-infected patient admissions have steadily increased over the last years at this referral center. Most patients were men, with a mean age of 32.3 years and presenting with the paucibacillary form of leprosy. The use of antiretroviral therapy (ART) was the only factor associated with type 1 reaction. Most patients were living in the metropolitan area and the north sub area of Rio de Janeiro City. CONCLUSION: Co-infected patients receiving ART have a greater chance to develop type 1 reaction. Patients living with both HIV and leprosy are likely to live in regions characterized by a high density impoverished population.
BACKGROUND: Many articles have shown that HIV infection can modify the clinical course of leprosy, but very scant epidemiological and clinical data about this co-infection are available in the peer-reviewed literature. METHODS: We herein describe the geographical distribution and demographic characteristics of 92 HIV/Mycobacterium leprae co-infectedpatients assisted in a Brazilian Leprosy referral center. A multivariate analysis was performed in order to establish clinical factors associated with type 1 reaction. RESULTS: Co-infected patient admissions have steadily increased over the last years at this referral center. Most patients were men, with a mean age of 32.3 years and presenting with the paucibacillary form of leprosy. The use of antiretroviral therapy (ART) was the only factor associated with type 1 reaction. Most patients were living in the metropolitan area and the north sub area of Rio de Janeiro City. CONCLUSION: Co-infected patients receiving ART have a greater chance to develop type 1 reaction. Patients living with both HIV and leprosy are likely to live in regions characterized by a high density impoverished population.
Entities:
Keywords:
Brazil; Leprosy and HIV co-infection; Social geography of leprosy; Type 1 reaction
Authors: Alba Llibre; Martin Dedicoat; Julie G Burel; Caroline Demangel; Matthew K O'Shea; Claudio Mauro Journal: Front Immunol Date: 2021-09-23 Impact factor: 7.561
Authors: Dayvison Francis Saraiva Freitas; Antonio Carlos Francesconi do Valle; Margarete Bernardo Tavares da Silva; Dayse Pereira Campos; Marcelo Rosandiski Lyra; Rogerio Valls de Souza; Valdiléa Gonçalves Veloso; Rosely Maria Zancopé-Oliveira; Francisco Inácio Bastos; Maria Clara Gutierrez Galhardo Journal: PLoS Negl Trop Dis Date: 2014-08-28
Authors: Tatiana Pereira da Silva; Tamiris Lameira Bittencourt; Ariane Leite de Oliveira; Rhana Berto da Silva Prata; Vinicius Menezes; Helen Ferreira; José Augusto da Costa Nery; Eliane Barbosa de Oliveira; Gilberto Marcelo Sperandio da Silva; Euzenir Nunes Sarno; Roberta Olmo Pinheiro Journal: Front Immunol Date: 2020-07-29 Impact factor: 7.561