Jon B Toledo1, Jon López-Azcárate2, David Garcia-Garcia3, Jorge Guridi4, Miguel Valencia5, Julio Artieda6, Jose Obeso7, Manuel Alegre8, Maria Rodriguez-Oroz9. 1. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain. Electronic address: jtoledo@mail.med.upenn.edu. 2. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain. Electronic address: jlopez.6@alumni.unav.es. 3. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address: dagarciagarcia@gmail.com. 4. Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain. Electronic address: jguridi@unav.es. 5. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain. Electronic address: mvustarroz@unav.es. 6. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain; Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain. Electronic address: jartieda@unav.es. 7. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain; Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address: jobeso52@gmail.com. 8. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain; Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain. Electronic address: malegre@unav.es. 9. Neurosciences Area, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain; Neurology and Neurosurgery, Clinica Universidad de Navarra, Av. Pio XII 36, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address: maria.rodriguezoroz@biodonostia.org.
Abstract
OBJECTIVE: Oscillatory activity in the beta band is increased in the subthalamic nucleus (STN) of Parkinson's disease (PD) patients. Rigidity and bradykinesia are associated with the low-beta component (13-20Hz) but the neurophysiological correlate of freezing of gait in PD has not been ascertained. METHODS: We evaluated the power and coherence of the low- and high-beta bands in the STN and cortex (EEG) of PD patients with (p-FOG) (n=14) or without freezing of gait (n-FOG) (n=8) in whom electrodes for chronic stimulation in the STN had been implanted for treatment with deep brain stimulation. RESULTS: p-FOG patients showed higher power in the high-beta band (F=11.6, p=0.002) that was significantly reduced after l-dopa administration along with suppression of FOG (F=4.6, p=0.042). High-beta cortico-STN coherence was maximal for midline cortical EEG electrodes, whereas the low-beta band was maximal for lateral electrodes (χ(2)=20.60, p<0.0001). CONCLUSIONS: The association between freezing of gait, high-beta STN oscillations and cortico-STN coherence suggests that this oscillatory activity might interfere in the frontal cortex-basal ganglia networks, thereby participating in the pathophysiology of FOG in PD.
OBJECTIVE: Oscillatory activity in the beta band is increased in the subthalamic nucleus (STN) of Parkinson's disease (PD) patients. Rigidity and bradykinesia are associated with the low-beta component (13-20Hz) but the neurophysiological correlate of freezing of gait in PD has not been ascertained. METHODS: We evaluated the power and coherence of the low- and high-beta bands in the STN and cortex (EEG) of PDpatients with (p-FOG) (n=14) or without freezing of gait (n-FOG) (n=8) in whom electrodes for chronic stimulation in the STN had been implanted for treatment with deep brain stimulation. RESULTS: p-FOGpatients showed higher power in the high-beta band (F=11.6, p=0.002) that was significantly reduced after l-dopa administration along with suppression of FOG (F=4.6, p=0.042). High-beta cortico-STN coherence was maximal for midline cortical EEG electrodes, whereas the low-beta band was maximal for lateral electrodes (χ(2)=20.60, p<0.0001). CONCLUSIONS: The association between freezing of gait, high-beta STN oscillations and cortico-STN coherence suggests that this oscillatory activity might interfere in the frontal cortex-basal ganglia networks, thereby participating in the pathophysiology of FOG in PD.
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