Marije Swets1, Jack Dekker2, Katelijne van Emmerik-van Oortmerssen3, Geert E Smid4, Filip Smit5, Lieuwe de Haan6, Robert A Schoevers7. 1. Arkin Mental Health and Addiction Treatment Centre, Amsterdam, The Netherlands. Electronic address: marijeswets@upcmail.nl. 2. Arkin Mental Health and Addiction Treatment Centre, Amsterdam, The Netherlands; Department of Clinical Psychology, VU Amsterdam, The Netherlands. 3. Arkin Mental Health and Addiction Treatment Centre, Amsterdam, The Netherlands; Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. 4. Foundation Centrum'45/Arq, Diemen, The Netherlands. 5. Trimbos-instituut, Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Health Care Research, VU University Medical Centre, Amsterdam, The Netherlands. 6. AMC, Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands. 7. Arkin Mental Health and Addiction Treatment Centre, Amsterdam, The Netherlands; Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Abstract
AIMS: The aims of this study were to conduct a meta-analysis and meta-regression to estimate the prevalence rates for obsessive compulsive symptoms (OCS) and obsessive compulsive disorder (OCD) in schizophrenia, and to investigate what influences these prevalence rates. METHOD: Studies were identified via an online OVID database search, including PsychInfo, Embase and Medline until December 2009. RESULTS: Forty-three studies summarizing outcomes for 3978 subjects met inclusion criteria. The mean OCD prevalence is 12.3%, slightly increasing to 13.6% after adjustment in meta-regression. The prevalence rate of OCS, defined as any obsession or compulsion is 30.7% (30.3% adjusted). Higher severity of OCS, DIGS assessment, and Sub-Saharan African origin of study are associated with a lower OCS/OCD prevalence rate, use of DSM-IV edition, Y-BOCS assessment and longer schizophrenia history are associated with a higher prevalence rate. CONCLUSION: The prevalence of OCS and OCD in schizophrenia is substantial, specifically in more chronic patient populations and is influenced by the method of assessment.
AIMS: The aims of this study were to conduct a meta-analysis and meta-regression to estimate the prevalence rates for obsessive compulsive symptoms (OCS) and obsessive compulsive disorder (OCD) in schizophrenia, and to investigate what influences these prevalence rates. METHOD: Studies were identified via an online OVID database search, including PsychInfo, Embase and Medline until December 2009. RESULTS: Forty-three studies summarizing outcomes for 3978 subjects met inclusion criteria. The mean OCD prevalence is 12.3%, slightly increasing to 13.6% after adjustment in meta-regression. The prevalence rate of OCS, defined as any obsession or compulsion is 30.7% (30.3% adjusted). Higher severity of OCS, DIGS assessment, and Sub-Saharan African origin of study are associated with a lower OCS/OCD prevalence rate, use of DSM-IV edition, Y-BOCS assessment and longer schizophrenia history are associated with a higher prevalence rate. CONCLUSION: The prevalence of OCS and OCD in schizophrenia is substantial, specifically in more chronic patient populations and is influenced by the method of assessment.
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