Srinivasan Vairavan1, Rathinaswamy B Govindan2, Naim Haddad3, Hubert Preissl4, Curtis L Lowery5, Eric Siegel6, Hari Eswaran7. 1. Graduate Institute of Technology, University of Arkansas at Little Rock, AR, USA. 2. Division of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA. 3. Weill Cornell Medical College in Qatar, Education City, Doha, Qatar. 4. SARA Fetal MEG Center, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Fetal MEG Center, University of Tuebingen, Tuebingen, Germany. 5. SARA Fetal MEG Center, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. 6. Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. 7. SARA Fetal MEG Center, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: eswaranhari@uams.edu.
Abstract
OBJECTIVE: To identify quantitative MEG indices of spontaneous brain activity for fetal neurological maturation in normal pregnancies and examine the effect of fetal state on these indices. METHODS: Spontaneous MEG brain activity was examined in 22 low-risk fetal recordings with gestational age (GA) ranging from 30 to 37 weeks. As major quantitative characteristics of spontaneous activity, burst duration (BD) and interburst interval (IBI) were studied in correlation with GA and fetal state. RESULTS: IBI showed a decrease with gestational age (-0.21 s/week, P=0.0031). This trend was only maintained in the quiet-sleep state. With respect to BD, no significant trends were detected with GA and state. CONCLUSION: IBI can be quantified as a fetal brain maturational parameter. The decrease in IBI over gestation was similar to the trend reported in the preterm neonatal EEG studies. Quiet sleep could be the optimal state to study such MEG maturational indices. SIGNIFICANCE: With further investigation, indices extracted from spontaneous fetal brain activity may serve as an early warning for fetal neurological distress.
OBJECTIVE: To identify quantitative MEG indices of spontaneous brain activity for fetal neurological maturation in normal pregnancies and examine the effect of fetal state on these indices. METHODS: Spontaneous MEG brain activity was examined in 22 low-risk fetal recordings with gestational age (GA) ranging from 30 to 37 weeks. As major quantitative characteristics of spontaneous activity, burst duration (BD) and interburst interval (IBI) were studied in correlation with GA and fetal state. RESULTS:IBI showed a decrease with gestational age (-0.21 s/week, P=0.0031). This trend was only maintained in the quiet-sleep state. With respect to BD, no significant trends were detected with GA and state. CONCLUSION:IBI can be quantified as a fetal brain maturational parameter. The decrease in IBI over gestation was similar to the trend reported in the preterm neonatal EEG studies. Quiet sleep could be the optimal state to study such MEG maturational indices. SIGNIFICANCE: With further investigation, indices extracted from spontaneous fetal brain activity may serve as an early warning for fetal neurological distress.
Authors: M Hayakawa; A Okumura; F Hayakawa; K Watanabe; M Ohshiro; Y Kato; R Takahashi; N Tauchi Journal: Arch Dis Child Fetal Neonatal Ed Date: 2001-05 Impact factor: 5.747
Authors: Curtis L Lowery; Joshua Q Campbell; James D Wilson; Pam Murphy; Hubert Preissl; Sharp F Malak; Hari Eswaran Journal: Am J Obstet Gynecol Date: 2003-06 Impact factor: 8.661