Literature DB >> 2436097

Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence.

O Nordström, T Melander, T Hökfelt, T Bartfai, M Goldstein.   

Abstract

The role of the neuropeptide galanin (GAL) in rat hypothalamus has been studied in different experimental models. Thus, the effect of GAL on potassium-induced dopamine release was analyzed in vitro, and the localization of GAL and GAL binding sites was studied with immunohistochemistry and receptor autoradiography, respectively. In the median eminence GAL and presumably dopamine were found to coexist in nerve endings and this area contained a high density of 125I-GAL binding sites. In vitro experiments revealed that GAL inhibited the release of [3H]dopamine in a dose-dependent manner (IC50 = 7-10 nM), possibly via a presynaptic receptor.

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Year:  1987        PMID： 2436097     DOI： 10.1016/0304-3940(87)90024-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  25 in total

Review 1.  Galanin.

Authors:  M E Vrontakis; A Torsello; H G Friesen
Journal:  J Endocrinol Invest       Date:  1991-10       Impact factor: 4.256

2.  Influence of chronic administration of antidepressant drugs on mRNA for galanin, galanin receptors, and tyrosine hydroxylase in catecholaminergic and serotonergic cell-body regions in rat brain.

Authors:  Molly L Rovin; Katherine A Boss-Williams; Reid S Alisch; James C Ritchie; David Weinshenker; Charles H K West; Jay M Weiss
Journal:  Neuropeptides       Date:  2012-02-10       Impact factor: 3.286

3.  Influence of the neuropeptide galanin on active avoidance in rats.

Authors:  A A Shandra; A M Mazarati; K L Servetskii
Journal:  Neurosci Behav Physiol       Date:  1994 Sep-Oct

4.  Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide.

Authors:  W E Schmidt; H Kratzin; K Eckart; D Drevs; G Mundkowski; A Clemens; S Katsoulis; H Schäfer; B Gallwitz; W Creutzfeldt
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

5.  Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus.

Authors:  G A Kinney; P J Emmerson; R J Miller
Journal:  J Neurosci       Date:  1998-05-15       Impact factor: 6.167

6.  Galanin-immunoreactive nerves in the rat iris: alterations induced by denervations.

Authors:  I Strömberg; H Björklund; T Melander; A Rökaeus; T Hökfelt; L Olson
Journal:  Cell Tissue Res       Date:  1987-11       Impact factor: 5.249

7.  Tissue-specific expression of the rat galanin gene.

Authors:  L M Kaplan; E R Spindel; K J Isselbacher; W W Chin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

8.  Immunocytochemical properties of stellate ganglion neurons during early postnatal development.

Authors:  Petr M Masliukov; Jean-Pierre Timmermans
Journal:  Histochem Cell Biol       Date:  2004-08-26       Impact factor: 4.304

9.  Distribution of galanin-binding sites in the monkey and human telencephalon: preliminary observations.

Authors:  C Köhler; A Persson; T Melander; E Theodorsson; G Sedvall; T Hökfelt
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

10.  Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures.

Authors:  Robert P Lisak; Joyce A Benjamins; Beverly Bealmear; Liljana Nedelkoska; Diane Studzinski; Ernest Retland; Bin Yao; Susan Land
Journal:  J Neuroinflammation       Date:  2009-01-21       Impact factor: 8.322
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