Dimitrios Poulikakos1, Debasish Banerjee2, Marek Malik3. 1. Renal and Transplantation Unit, St. George's, University of London, London, United Kingdom; Cardiovascular Sciences Research Centre, St. George's, University of London, London, United Kingdom. Electronic address: Dimitrios.Poulikakos@stgeorges.nhs.uk. 2. Renal and Transplantation Unit, St. George's, University of London, London, United Kingdom; Cardiovascular Sciences Research Centre, St. George's, University of London, London, United Kingdom. 3. Imperial College of Science Technology and Medicine, London, United Kingdom.
Abstract
BACKGROUND: Sudden cardiac death is common in patients receiving regular hemodialysis (HD). We recently demonstrated that selected repolarization descriptors calculated from electrocardiographic monitoring during HD demonstrate intra-subject stability. In this study we followed up the initial cohort for major arrhythmic events (MAE). METHODS: Holter electrocardiograms (ECGs) were recorded during dialysis in 81 HD patients and repeated 5 times at 2 week intervals. The QRS-to-T angle (TCRT), the principal component analysis (PCA) ratio and the T wave morphology dispersion (TMD) were calculated in overlapping 10 second ECG segments and averaged overall recordings in each patient. Patients were followed up for MAE and non-arrhythmic mortality. RESULTS: During 18 ± 3 months, 3 patients experienced MAE. Compared to others, MAE patients exhibited extreme TCRT and TMD values and minimal intradialytic changes. CONCLUSION: The prognostic value of repolarization descriptors from intradialytic monitoring should be assessed prospectively.
BACKGROUND: Sudden cardiac death is common in patients receiving regular hemodialysis (HD). We recently demonstrated that selected repolarization descriptors calculated from electrocardiographic monitoring during HD demonstrate intra-subject stability. In this study we followed up the initial cohort for major arrhythmic events (MAE). METHODS: Holter electrocardiograms (ECGs) were recorded during dialysis in 81 HD patients and repeated 5 times at 2 week intervals. The QRS-to-T angle (TCRT), the principal component analysis (PCA) ratio and the T wave morphology dispersion (TMD) were calculated in overlapping 10 second ECG segments and averaged overall recordings in each patient. Patients were followed up for MAE and non-arrhythmic mortality. RESULTS: During 18 ± 3 months, 3 patients experienced MAE. Compared to others, MAE patients exhibited extreme TCRT and TMD values and minimal intradialytic changes. CONCLUSION: The prognostic value of repolarization descriptors from intradialytic monitoring should be assessed prospectively.
Authors: Sofia Skampardoni; Dimitrios Poulikakos; Marek Malik; Darren Green; Philip A Kalra Journal: Nephrol Dial Transplant Date: 2019-07-01 Impact factor: 5.992
Authors: Paul R Roberts; Donah Zachariah; John M Morgan; Arthur M Yue; Elizabeth F Greenwood; Patrick C Phillips; Philip A Kalra; Darren Green; Robert J Lewis; Paul R Kalra Journal: PLoS One Date: 2017-12-14 Impact factor: 3.240