| Literature DB >> 24360797 |
Jin Hou1, Ye Zhou2, Yuanyuan Zheng2, Jia Fan3, Weiping Zhou4, Irene O L Ng5, Huichuan Sun3, Lunxiu Qin3, Shuangjian Qiu3, Joyce M F Lee5, Chung-Mau Lo5, Kwan Man5, Yuan Yang4, Yun Yang4, Yingyun Yang6, Qian Zhang1, Xuhui Zhu2, Nan Li2, Zhengxin Wang7, Guoshan Ding7, Shi-Mei Zhuang8, Limin Zheng8, Xiaoling Luo9, Yuan Xie9, Anmin Liang9, Zhugang Wang10, Ming Zhang11, Qiang Xia11, Tingbo Liang12, Yizhi Yu2, Xuetao Cao13.
Abstract
In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-α (IFN-α) would be very useful in the clinic. We found that expression of retinoic acid-inducible gene-I (RIG-I), an IFN-stimulated gene, was significantly downregulated in human HCC tissues. Patients with low RIG-I expression had shorter survival and poorer response to IFN-α therapy, suggesting that RIG-I is a useful prognosis and IFN-α response predictor for HCC patients. Mechanistically, RIG-I enhances IFN-α response by amplifying IFN-α effector signaling via strengthening STAT1 activation. Furthermore, we found that RIG-I deficiency promotes HCC carcinogenesis and that hepatic RIG-I expression is lower in men than in women. RIG-I may therefore be a tumor suppressor in HCC and contribute to HCC gender disparity.Entities:
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Year: 2013 PMID： 24360797 DOI： 10.1016/j.ccr.2013.11.011
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743