Literature DB >> 24360540

Biomarker modeling of Alzheimer's disease.

Clifford R Jack1, David M Holtzman2.   

Abstract

Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in therapeutic trials. Current AD biomarkers fall into two categories: biomarkers of amyloid-β plaques and of tau-related neurodegeneration. Three of the five are imaging measures and two are cerebrospinal fluid analytes. AD biomarkers do not evolve in an identical manner but rather in a sequential but temporally overlapping manner. Models of the temporal evolution of AD biomarkers can take the form of plots of biomarker severity (degree of abnormality) versus time. In this Review, we discuss several time-dependent models of AD that take into consideration varying age of onset (early versus late) and the influence of aging and co-occurring brain pathologies that commonly arise in the elderly.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24360540      PMCID： PMC3928967          DOI： 10.1016/j.neuron.2013.12.003

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  156 in total

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Authors:  Jonathan H Morra; Zhuowen Tu; Liana G Apostolova; Amity E Green; Christina Avedissian; Sarah K Madsen; Neelroop Parikshak; Arthur W Toga; Clifford R Jack; Norbert Schuff; Michael W Weiner; Paul M Thompson
Journal:  Neuroimage       Date:  2008-11-08       Impact factor: 6.556

2.  Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls.

Authors:  Jonathan H Morra; Zhuowen Tu; Liana G Apostolova; Amity E Green; Christina Avedissian; Sarah K Madsen; Neelroop Parikshak; Xue Hua; Arthur W Toga; Clifford R Jack; Michael W Weiner; Paul M Thompson
Journal:  Neuroimage       Date:  2008-07-16       Impact factor: 6.556

Review 3.  Neuroimaging outcomes in clinical trials in Alzheimer's disease.

Authors:  G B Frisoni; A Delacourte
Journal:  J Nutr Health Aging       Date:  2009-03       Impact factor: 4.075

4.  Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly.

Authors:  Anne M Fagan; Denise Head; Aarti R Shah; Daniel Marcus; Mark Mintun; John C Morris; David M Holtzman
Journal:  Ann Neurol       Date:  2009-02       Impact factor: 10.422

5.  Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia.

Authors:  Gil D Rabinovici; William J Jagust; Ansgar J Furst; Jennifer M Ogar; Caroline A Racine; Elizabeth C Mormino; James P O'Neil; Rayhan A Lal; Nina F Dronkers; Bruce L Miller; Maria Luisa Gorno-Tempini
Journal:  Ann Neurol       Date:  2008-10       Impact factor: 10.422

6.  MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study.

Authors:  J L Whitwell; K A Josephs; M E Murray; K Kantarci; S A Przybelski; S D Weigand; P Vemuri; M L Senjem; J E Parisi; D S Knopman; B F Boeve; R C Petersen; D W Dickson; C R Jack
Journal:  Neurology       Date:  2008-09-02       Impact factor: 9.910

7.  Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage.

Authors:  Prashanthi Vemuri; Jennifer L Whitwell; Kejal Kantarci; Keith A Josephs; Joseph E Parisi; Maria S Shiung; David S Knopman; Bradley F Boeve; Ronald C Petersen; Dennis W Dickson; Clifford R Jack
Journal:  Neuroimage       Date:  2008-05-20       Impact factor: 6.556

Review 8.  Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis.

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Journal:  Neuron       Date:  2008-11-26       Impact factor: 17.173

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10.  Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.

Authors:  Catherine M Roe; Mark A Mintun; Gina D'Angelo; Chengjie Xiong; Elizabeth A Grant; John C Morris
Journal:  Arch Neurol       Date:  2008-11
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  307 in total

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Authors:  Clifford R Jack; David S Knopman; Gaël Chételat; Dennis Dickson; Anne M Fagan; Giovanni B Frisoni; William Jagust; Elizabeth C Mormino; Ronald C Petersen; Reisa A Sperling; Wiesje M van der Flier; Victor L Villemagne; Pieter J Visser; Stephanie J B Vos
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5.  Occupational attainment influences survival in autopsy-confirmed frontotemporal degeneration.

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6.  ApoE4 Accelerates Early Seeding of Amyloid Pathology.

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7.  Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.

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8.  Higher-order spectral analysis of spontaneous speech signals in Alzheimer's disease.

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9.  BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.

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10.  Focal alteration of the intraretinal layers in neurodegenerative disorders.

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