Catherine L Granger1, Christine F McDonald2, Louis Irving3, Ross A Clark4, Karla Gough5, Andrew Murnane5, Linda Mileshkin5, Meinir Krishnasamy5, Linda Denehy6. 1. Department of Physiotherapy, The University of Melbourne, Level 7, Alan Gilbert Building, Parkville, Victoria 3010, Australia; Institute for Breathing and Sleep, Austin Hospital, Heidelberg, Victoria 3084, Australia. Electronic address: catherine.granger@mh.org.au. 2. Institute for Breathing and Sleep, Austin Hospital, Heidelberg, Victoria 3084, Australia; Department of Respiratory and Sleep Medicine, Austin Hospital, Heidelberg, Victoria 3084, Australia. 3. Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Parkville, Victoria 3010, Australia. 4. Department of Physiotherapy, The University of Melbourne, Level 7, Alan Gilbert Building, Parkville, Victoria 3010, Australia. 5. Department of Cancer Experiences Research, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia. 6. Department of Physiotherapy, The University of Melbourne, Level 7, Alan Gilbert Building, Parkville, Victoria 3010, Australia; Institute for Breathing and Sleep, Austin Hospital, Heidelberg, Victoria 3084, Australia.
Abstract
OBJECTIVES: Physical activity has been infrequently measured objectively in non-small cell lung cancer (NSCLC). We aimed to investigate levels of physical activity, functional and patient reported outcomes at diagnosis and over six months in participants with recently diagnosed NSCLC and compare results with both physical activity guidelines and outcomes of similar-aged healthy individuals. METHODS: This prospective observational study assessed 50 individuals from three Australian tertiary hospitals with stage I-IIIB NSCLC at diagnosis, then 10 weeks and six months later. Thirty five healthy individuals without cancer were assessed once. Outcome measures included tri-axial accelerometery (number of steps per day), six minute walk distance (6MWD), muscle strength and questionnaires including health-related quality of life (HRQoL). RESULTS: Individuals with NSCLC were engaged in significantly less physical activity than similar-aged healthy individuals, with 60% not meeting physical activity guidelines. At diagnosis they had worse quadriceps strength, nutritional status and HRQoL. Over six months, participants with NSCLC experienced decline in self-reported physical activity, 6MWD and muscle strength, and worsening symptoms. CONCLUSION: At diagnosis individuals with NSCLC engage in less physical activity, are weaker and more depressed than healthy individuals and their self-reported physical activity declines over six months. Future studies are required to investigate the efficacy of interventions to increase physical activity. Crown
OBJECTIVES: Physical activity has been infrequently measured objectively in non-small cell lung cancer (NSCLC). We aimed to investigate levels of physical activity, functional and patient reported outcomes at diagnosis and over six months in participants with recently diagnosed NSCLC and compare results with both physical activity guidelines and outcomes of similar-aged healthy individuals. METHODS: This prospective observational study assessed 50 individuals from three Australian tertiary hospitals with stage I-IIIB NSCLC at diagnosis, then 10 weeks and six months later. Thirty five healthy individuals without cancer were assessed once. Outcome measures included tri-axial accelerometery (number of steps per day), six minute walk distance (6MWD), muscle strength and questionnaires including health-related quality of life (HRQoL). RESULTS: Individuals with NSCLC were engaged in significantly less physical activity than similar-aged healthy individuals, with 60% not meeting physical activity guidelines. At diagnosis they had worse quadriceps strength, nutritional status and HRQoL. Over six months, participants with NSCLC experienced decline in self-reported physical activity, 6MWD and muscle strength, and worsening symptoms. CONCLUSION: At diagnosis individuals with NSCLC engage in less physical activity, are weaker and more depressed than healthy individuals and their self-reported physical activity declines over six months. Future studies are required to investigate the efficacy of interventions to increase physical activity. Crown
Authors: Vinicius Cavalheri; Chris Burtin; Vittoria R Formico; Mika L Nonoyama; Sue Jenkins; Martijn A Spruit; Kylie Hill Journal: Cochrane Database Syst Rev Date: 2019-06-17
Authors: Sean M Stokes; Elliot Wakeam; Mara B Antonoff; Leah M Backhus; Robert A Meguid; David Odell; Thomas K Varghese Journal: J Thorac Dis Date: 2019-03 Impact factor: 2.895
Authors: Vinicius Cavalheri; Sue Jenkins; Nola Cecins; Martin Phillips; Lucas H Sanders; Kylie Hill Journal: Chron Respir Dis Date: 2015-12-31 Impact factor: 2.444