N L Nixon1, P F Liddle, E Nixon, G Worwood, M Liotti, L Palaniyappan. 1. N. L. Nixon, MBBS, MRCPsych, MMedSci, P. F. Liddle, BMBCh, MRCPsych, PhD, E. Nixon, PhD, G. Worwood, MBBCh, MRCPsych, MMedSci, Division of Psychiatry and Applied Psychology, Institute of Mental Health, University of Nottingham, Nottingham, UK; M. Liotti, MD, PhD, Department of Psychology, Simon Fraser University, Burnaby, Canada; L. Palaniyappan, MBBS, MRCPsych, PhD, Centre for Translational Neuroimaging, Division of Psychiatry and Applied Psychology, Institute of Mental Health, University of Nottingham, Nottingham, UK.
Abstract
BACKGROUND: Patients in recovery following episodes of major depressive disorder (MDD) remain highly vulnerable to future recurrence. Although psychological determinants of this risk are well established, little is known about associated biological mechanisms. Recent work has implicated the default mode network (DMN) in this vulnerability but specific hypotheses remain untested within the high risk, recovered state of MDD. AIMS: To test the hypothesis that there is excessive DMN functional connectivity during task performance within recovered-state MDD and to test for connected DMN cortical gyrification abnormalities. METHOD: A multimodal structural and functional magnetic resonance imaging (fMRI) study, including task-based functional connectivity and cortical folding analysis, comparing 20 recovered-state patients with MDD with 20 matched healthy controls. RESULTS: The MDD group showed significant task-based DMN hyperconnectivity, associated with hypogyrification of key DMN regions (bilateral precuneus). CONCLUSIONS: This is the first evidence of connected structural and functional DMN abnormalities in recovered-state MDD, supporting recent hypotheses on biological-level vulnerability.
BACKGROUND:Patients in recovery following episodes of major depressive disorder (MDD) remain highly vulnerable to future recurrence. Although psychological determinants of this risk are well established, little is known about associated biological mechanisms. Recent work has implicated the default mode network (DMN) in this vulnerability but specific hypotheses remain untested within the high risk, recovered state of MDD. AIMS: To test the hypothesis that there is excessive DMN functional connectivity during task performance within recovered-state MDD and to test for connected DMN cortical gyrification abnormalities. METHOD: A multimodal structural and functional magnetic resonance imaging (fMRI) study, including task-based functional connectivity and cortical folding analysis, comparing 20 recovered-state patients with MDD with 20 matched healthy controls. RESULTS: The MDD group showed significant task-based DMN hyperconnectivity, associated with hypogyrification of key DMN regions (bilateral precuneus). CONCLUSIONS: This is the first evidence of connected structural and functional DMN abnormalities in recovered-state MDD, supporting recent hypotheses on biological-level vulnerability.
Authors: Elizabeth A Bartlett; Daniel N Klein; Kaiqiao Li; Christine DeLorenzo; Roman Kotov; Greg Perlman Journal: Biol Psychiatry Date: 2019-05-07 Impact factor: 13.382
Authors: Erdem Pulcu; Roland Zahn; Jorge Moll; Paula D Trotter; Emma J Thomas; Gabriella Juhasz; J F William Deakin; Ian M Anderson; Barbara J Sahakian; Rebecca Elliott Journal: Neuroimage Clin Date: 2014-04-21 Impact factor: 4.881