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Literature DB >> 24356302

A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides.

Abstract

Highlight describes the recently discovered prodrug activation mechanism found in the biosynthesis of nonribosomally produced peptides and peptide/polyketide hybrids as well as related mechanisms.

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Year: 2014 PMID： 24356302 DOI： 10.1039/c3np70081j

Source DB: PubMed Journal: Nat Prod Rep ISSN： 0265-0568 Impact factor: 13.423

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Cited

13 in total

1. Low-molecular-weight metabolites secreted by Paenibacillus larvae as potential virulence factors of American foulbrood.

Authors: Hedwig-Annabell Schild; Sebastian W Fuchs; Helge B Bode; Bernd Grünewald
Journal: Appl Environ Microbiol Date: 2014-02-07 Impact factor: 4.792

2. Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.

Authors: Philipp Engel; Maria I Vizcaino; Jason M Crawford
Journal: Appl Environ Microbiol Date: 2015-02 Impact factor: 4.792

3. Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis.

Authors: Yue Zhang; Wan-Hong Wen; Jin-Yue Pu; Man-Cheng Tang; Liwen Zhang; Chao Peng; Yuquan Xu; Gong-Li Tang
Journal: Proc Natl Acad Sci U S A Date: 2018-10-16 Impact factor: 11.205

Review 4. From Soil Amendments to Controlling Autophagy: Supporting Plant Metabolism under Conditions of Water Shortage and Salinity.

Authors: Hans-Werner Koyro; Bernhard Huchzermeyer
Journal: Plants (Basel) Date: 2022-06-22

5. Structural basis of colibactin activation by the ClbP peptidase.

Authors: José A Velilla; Matthew R Volpe; Grace E Kenney; Richard M Walsh; Emily P Balskus; Rachelle Gaudet
Journal: Nat Chem Biol Date: 2022-10-17 Impact factor: 16.174

6. Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.

Authors: Yi-Ming Shi; Merle Hirschmann; Yan-Ni Shi; Shabbir Ahmed; Desalegne Abebew; Nicholas J Tobias; Peter Grün; Jan J Crames; Laura Pöschel; Wolfgang Kuttenlochner; Christian Richter; Jennifer Herrmann; Rolf Müller; Aunchalee Thanwisai; Sacha J Pidot; Timothy P Stinear; Michael Groll; Yonggyun Kim; Helge B Bode
Journal: Nat Chem Date: 2022-04-25 Impact factor: 24.274

A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides.

1. Low-molecular-weight metabolites secreted by Paenibacillus larvae as potential virulence factors of American foulbrood.

2. Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.

3. Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis.

Review 4. From Soil Amendments to Controlling Autophagy: Supporting Plant Metabolism under Conditions of Water Shortage and Salinity.

5. Structural basis of colibactin activation by the ClbP peptidase.

6. Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.

7. The colibactin warhead crosslinks DNA.

8. Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis.

9. Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis.

Review 10. Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking.