| Literature DB >> 24355129 |
Tenna Juul Schrøder1, Søren Christensen1, Samsa Lindberg1, Morten Langgård1, Laurent David1, Philip J Maltas1, Jørgen Eskildsen1, Jan Jacobsen1, Lena Tagmose1, Klaus Bæk Simonsen1, Lars Christian Biilmann Rønn1, Inge E M de Jong1, Ibrahim J Malik1, Jens-Jakob Karlsson1, Christoffer Bundgaard1, Jan Egebjerg1, Jeffrey B Stavenhagen1, Dorthe Strandbygård2, Søren Thirup2, Jacob Lauwring Andersen2, Srinivas Uppalanchi3, Sridhar Pervaram3, Shiva Prasad Kasturi3, Pradheep Eradi3, Durga Rao Sakumudi3, Stephen P Watson4.
Abstract
The identification of the novel, selective, orally bioavailable Sortilin inhibitor AF38469 is described. Structure-activity relationships and syntheses are reported, along with an X-ray crystal structure of the sortilin-AF38469 protein-inhibitor complex.Entities:
Keywords: AF38469; AF40431; Neurotensin; Protein-inhibitor complex; Sortilin; Sortilin crystal structure; Sorting receptor; VPS10P
Mesh：
Substances：
Year: 2013 PMID： 24355129 DOI： 10.1016/j.bmcl.2013.11.046
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823