Shweta Nayak1, Melanie E Ochalski2, Bo Fu3, Kathryn-Mary Wakim4, Tian Jao Chu5, Xinxin Dong3, Anthony N Wakim6. 1. Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania. 2. Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Magee-Women's Research Institute, Pittsburgh, Pennsylvania; Fertility Center, York, Pennsylvania. 3. University of Pittsburgh, Pittsburgh, Pennsylvania. 4. Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. 5. Magee-Women's Research Institute, Pittsburgh, Pennsylvania. 6. Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: wakian@mail.magee.edu.
Abstract
OBJECTIVE: To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels. DESIGN: Prospective cohort study. SETTING: Academic IVF center. PATIENT(S): One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Implantation, pregnancy, and spontaneous abortion rates were collected. RESULT(S): Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance. CONCLUSION(S): Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.
OBJECTIVE: To evaluate the distribution of P levels on the day of oocyte retrieval as it relates to pregnancy outcome in an antagonist protocol, which may be at higher risk for elevated P levels. DESIGN: Prospective cohort study. SETTING: Academic IVF center. PATIENT(S): One hundred eighty-six women undergoing controlled ovarian hyperstimulation with an antagonist protocol. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Implantation, pregnancy, and spontaneous abortion rates were collected. RESULT(S): Implantation rate (positive hCG 14 days after ET) and pregnancy rate were significantly higher when the P level was <12 ng/mL on the day of oocyte retrieval. Miscarriage rates were higher when the P level was ≥12 ng/mL, although this did not reach statistical significance. CONCLUSION(S): Elevated P on the day of oocyte retrieval is associated with significantly lower implantation and ongoing pregnancy rates. This is the first study to date to both uncover the distribution of P on the day of oocyte retrieval in an antagonist cycle and determine the impact an elevation may have on pregnancy outcome.