Literature DB >> 24355046

Fertility in patients with congenital adrenal hyperplasia.

David E Reichman1, Perrin C White2, Maria I New3, Zev Rosenwaks4.   

Abstract

Congenital adrenal hyperplasia (CAH) is the most frequently encountered genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; patients with either 21- hydroxylase or 11β-hydroxylase deficiency thus face immense challenges to their fertility. Given the relevance of CAH in reproductive medicine as well as the diagnostic challenges posed by the phenotypic overlap with polycystic ovary syndrome, we review the reproductive pahophysiology of both classic and nonclassic CAH and present contemporary treatment options.
Copyright © 2014. Published by Elsevier Inc.

Entities:  

Keywords:  11b-hydroxylase; 21 hydroxylase; CAH; genotype; infertility; phenotype; steroidogenesis

Mesh：

Substances：

Year:  2013        PMID： 24355046     DOI： 10.1016/j.fertnstert.2013.11.002

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


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