| Literature DB >> 24354184 |
Ksenya M Tabakmakher1, Vladimir A Denisenko1, Alla G Guzii1, Pavel S Dmitrenok1, Sergey A Dyshlovoy1, Hyi-Seung Lee2, Tatyana N Makarieva1.
Abstract
A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and ma ss spectrometric da ta. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 microM and 4.3 pM, respectively.Entities:
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Year: 2013 PMID： 24354184
Source DB: PubMed Journal: Nat Prod Commun ISSN： 1555-9475 Impact factor: 0.986