Literature DB >> 2435412

A single bone marrow-derived stromal cell type supports the in vitro growth of early lymphoid and myeloid cells.

P Hunt, D Robertson, D Weiss, D Rennick, F Lee, O N Witte.   

Abstract

A clonal cell line (ALC) derived from murine bone marrow stroma is capable of supporting the continuous, in vitro growth of early lymphoid and myeloid cell populations. The growth-promoting effects of ALC are in part mediated through M-CSF and a pre-B cell growth factor, both of which accumulate in ALC-culture supernatant. To analyze the lymphoid growth factor produced by ALC cells, we derived a pre-B cell indicator line that is dependent on ALC-growth-conditioned medium. Using a combination of biological and biochemical analyses, we have established that the pre-B cell growth factor produced by ALC cells is distinct from IL-1, IL-2, IL-3, and IL-4 (BSF-1), suggesting that the early stages of B-cell development are regulated by a unique stroma-derived growth factor.

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Year:  1987        PMID： 2435412     DOI： 10.1016/0092-8674(87)90708-2

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  43 in total

1.  Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro.

Authors:  R Palacios; J Samaridis
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

2.  Transcriptional down-regulation of N-myc expression during B-cell development.

Authors:  R K Smith; K Zimmerman; G D Yancopoulos; A Ma; F W Alt
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

3.  Analysis of B-cell abnormalities in autoimmune mice by in vitro culture system using two types of bone marrow stromal cell clone.

Authors:  J Ohmori; T Ezaki; M Kotani
Journal:  Immunology       Date:  1990-12       Impact factor: 7.397

4.  Sequence of the Lyb-2 B-cell differentiation antigen defines a gene superfamily of receptors with inverted membrane orientation.

Authors:  E Nakayama; I von Hoegen; J R Parnes
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

5.  Establishment of an osteogenic cell line derived from adult mouse bone marrow stroma by use of a recombinant retrovirus.

Authors:  E Mathieu; G Schoeters; F vander Plaetse; J Merregaert
Journal:  Calcif Tissue Int       Date:  1992-04       Impact factor: 4.333

6.  In vitro Differentiation Potential of Mesenchymal Stem Cells.

Authors:  Jeffrey M Gimble; Farshid Guilak; Mark E Nuttall; Solomon Sathishkumar; Martin Vidal; Bruce A Bunnell
Journal:  Transfus Med Hemother       Date:  2008-05-08       Impact factor: 3.747

7.  Hemopoiesis in long-term stroma-dependent cultures from lymphoid tissue: production of cells with myeloid/dendritic characteristics.

Authors:  K Ni; H C O'Neill
Journal:  In Vitro Cell Dev Biol Anim       Date:  1998-04       Impact factor: 2.416

8.  Response of bone marrow stromal cells to adipogenic antagonists.

Authors:  J M Gimble; M A Dorheim; Q Cheng; P Pekala; S Enerback; L Ellingsworth; P W Kincade; C S Wang
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

9.  Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

Authors:  C P Chiu; C Moulds; R L Coffman; D Rennick; F Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

10.  Early pre-B-cell transformation induced by the v-fms oncogene in long-term mouse bone marrow cultures.

Authors:  G V Borzillo; C J Sherr
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272
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