Zareen Kiran1, Bader Faiyaz Zuberi2, Daniah Anis3, Rashid Qadeer4, Khalid Hassan5, Salahuddin Afsar6. 1. Dr. Zareen Kiran, MBBS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan. 2. Dr. Bader Faiyaz Zuberi, FCPS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan. 3. Dr. Daniah Anis, MBBS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan. 4. Dr. Rashid Qadeer, FCPS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan. 5. Dr. Khalid Hassan, FCPS, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan. 6. Prof. Salahuddin Afsar, FRCP, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Abstract
OBJECTIVE: To determine insulin resistance in non-diabetic chronic hepatitis C patients using Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). METHODOLOGY: Patients having anti-HCV positive were included in this study. Patients with diabetes mellitus, thyroid disease, hyperlipidemias, hypercortisolism and infective diseases other than hepatitis C were excluded. Age, weight, height and absence of diabetes were documented. Fasting blood glucose and fasting insulin levels were done. Body mass index and insulin resistance was calculated using the formulas. Patients having insulin resistance using formula HOMA-IR>2.5 were labeled as insulin resistant. Data was analyzed using SPSS-18. RESULTS: One hundred and fifty five patients according to sample size estimation were enrolled, in whom HOMA-IR was calculated, the mean value was found to be 2.47 ±1.30. A total of 79 (51%) of patients had HOMA-IR more than 2.5 showing insulin resistance. CONCLUSION: In a third world country like Pakistan, where there is a high prevalence of hepatitis C infection, the consequences of the disease are also very common. Insulin resistance was found in 51% of patients with chronic hepatitis C.
OBJECTIVE: To determine insulin resistance in non-diabetic chronic hepatitis Cpatients using Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). METHODOLOGY:Patients having anti-HCV positive were included in this study. Patients with diabetes mellitus, thyroid disease, hyperlipidemias, hypercortisolism and infective diseases other than hepatitis C were excluded. Age, weight, height and absence of diabetes were documented. Fasting blood glucose and fasting insulin levels were done. Body mass index and insulin resistance was calculated using the formulas. Patients having insulin resistance using formula HOMA-IR>2.5 were labeled as insulin resistant. Data was analyzed using SPSS-18. RESULTS: One hundred and fifty five patients according to sample size estimation were enrolled, in whom HOMA-IR was calculated, the mean value was found to be 2.47 ±1.30. A total of 79 (51%) of patients had HOMA-IR more than 2.5 showing insulin resistance. CONCLUSION: In a third world country like Pakistan, where there is a high prevalence of hepatitis C infection, the consequences of the disease are also very common. Insulin resistance was found in 51% of patients with chronic hepatitis C.
Entities:
Keywords:
Chronic Hepatitis C Infection; Diabetes Mellitus; HOMA-IR; Insulin Resistance
Authors: J Westin; M Lagging; A P Dhillon; G Norkrans; A I Romero; J-M Pawlotsky; S Zeuzem; S W Schalm; E Verheij-Hart; F Negro; G Missale; A U Neumann; K Hellstrand Journal: J Viral Hepat Date: 2007-01 Impact factor: 3.728
Authors: Mahmoud Khattab; Mohammed Eslam; Mohammed Ahmed Sharwae; Mohammed Shatat; Ahmed Ali; Lamia Hamdy Journal: Am J Gastroenterol Date: 2010-03-16 Impact factor: 10.864