Literature DB >> 2435283

Loss of brown adipose tissue uncoupling protein mRNA on deacclimation of cold-exposed rats.

S Reichling, R G Ridley, H V Patel, C B Harley, K B Freeman.   

Abstract

The effect of environmental temperature on the level of uncoupling protein mRNA from rat brown adipose tissue was examined using a cDNA probe. A 4.4 fold increase in the mRNA level was observed after 1 day exposure of rats to 6 degrees C, which was followed by a slow loss with longer times of exposure. When rats were returned to a thermoneutral environment, there was a dramatic loss of uncoupling protein mRNA within 1 day. Comparison wih poly(A)+ RNA levels suggest that the response to temperature is specific for uncoupling protein mRNA.

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Year:  1987        PMID: 2435283     DOI: 10.1016/0006-291x(87)91470-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  7 in total

1.  Selective loss of the uncoupling protein from light versus heavy mitochondria of brown adipocytes after a decrease in noradrenergic stimulation in vivo and in vitro.

Authors:  M L Bonet; F Serra; J C Matamala; F J García-Palmer; A Palou
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

2.  Effect of unilateral surgical denervation of brown adipose tissue on uncoupling protein mRNA level and cytochrom-c-oxidase activity in the Djungarian hamster.

Authors:  M Klingenspor; A Meywirth; S Stöhr; G Heldmaier
Journal:  J Comp Physiol B       Date:  1994       Impact factor: 2.200

3.  Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation?

Authors:  C Picó; D Herron; A Palou; A Jacobsson; B Cannon; J Nedergaard
Journal:  Biochem J       Date:  1994-08-15       Impact factor: 3.857

4.  Adaptative decrease in expression of the mRNA for uncoupling protein and subunit II of cytochrome c oxidase in rat brown adipose tissue during pregnancy and lactation.

Authors:  I Martin; M Giralt; O Viñas; R Iglesias; T Mampel; F Villarroya
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

Review 5.  The pathophysiology of mitochondrial disease as modeled in the mouse.

Authors:  Douglas C Wallace; Weiwei Fan
Journal:  Genes Dev       Date:  2009-08-01       Impact factor: 11.361

6.  Convertible adipose tissue in mice.

Authors:  D Loncar
Journal:  Cell Tissue Res       Date:  1991-10       Impact factor: 5.249

Review 7.  Leptin: Is It Thermogenic?

Authors:  Alexander W Fischer; Barbara Cannon; Jan Nedergaard
Journal:  Endocr Rev       Date:  2020-04-01       Impact factor: 19.871

  7 in total

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