Literature DB >> 24352452

Papillomavirus E6 PDZ interactions can be replaced by repression of p53 to promote episomal human papillomavirus genome maintenance.

Nicole Brimer1, Scott B Vande Pol.   

Abstract

Cancer-associated human papillomaviruses (HPVs) express E6 oncoproteins that target the degradation of p53 and have a carboxy-terminal PDZ ligand that is required for stable episomal maintenance of the HPV genome. We find that the E6 PDZ ligand can be deleted and the HPV genome stably maintained if cellular p53 is inactivated. This indicates that the E6-PDZ interaction promotes HPV genome maintenance at least in part by neutralization of an activity that can arise from residual undegraded p53.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24352452      PMCID： PMC3958089          DOI： 10.1128/JVI.02360-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

1.  Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS.

Authors:  B L Allen-Hoffmann; S J Schlosser; C A Ivarie; C A Sattler; L F Meisner; S L O'Connor
Journal:  J Invest Dermatol       Date:  2000-03       Impact factor: 8.551

2.  Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins.

Authors:  S S Lee; B Glaunsinger; F Mantovani; L Banks; R T Javier
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

3.  Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins.

Authors:  Ming Jing; Joanna Bohl; Nicole Brimer; Michael Kinter; Scott B Vande Pol
Journal:  J Virol       Date:  2006-12-13       Impact factor: 5.103

4.  Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance.

Authors:  Lietta Nicolaides; Clare Davy; Kenneth Raj; Christian Kranjec; Lawrence Banks; John Doorbar
Journal:  Virology       Date:  2011-04-13       Impact factor: 3.616

5.  The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth.

Authors:  William C Spanos; Andrew Hoover; George F Harris; Shu Wu; Guinevere L Strand; Mary E Anderson; Aloysius J Klingelhutz; Wiljan Hendriks; Aaron D Bossler; John H Lee
Journal:  J Virol       Date:  2007-12-26       Impact factor: 5.103

6.  Human papillomavirus E6 regulates the cytoskeleton dynamics of keratinocytes through targeted degradation of p53.

Authors:  Brooke Cooper; Nicole Brimer; Scott B Vande Pol
Journal:  J Virol       Date:  2007-09-05       Impact factor: 5.103

Review 7.  Papillomaviruses in the causation of human cancers - a brief historical account.

Authors:  Harald zur Hausen
Journal:  Virology       Date:  2009-01-08       Impact factor: 3.616

8.  Expression of the human papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivation.

Authors:  Xiaobo Zhou; Karl Münger
Journal:  Virology       Date:  2009-01-08       Impact factor: 3.616

Review 9.  The papillomavirus E7 proteins.

Authors:  Ann Roman; Karl Munger
Journal:  Virology       Date:  2013-05-31       Impact factor: 3.616

10.  High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner.

Authors:  Siaw Shi Boon; Lawrence Banks
Journal:  J Virol       Date:  2012-11-21       Impact factor: 5.103
View more
  19 in total

1.  The Human Papillomavirus E6 PDZ Binding Motif Links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity.

Authors:  Jayashree Thatte; Paola Massimi; Miranda Thomas; Siaw Shi Boon; Lawrence Banks
Journal:  J Virol       Date:  2018-07-31       Impact factor: 5.103

2.  PDZ Domain-Containing Protein NHERF-2 Is a Novel Target of Human Papillomavirus 16 (HPV-16) and HPV-18.

Authors:  Nathaniel Edward Bennett Saidu; Vedrana Filić; Miranda Thomas; Vanessa Sarabia-Vega; Anamaria Đukić; Frane Miljković; Lawrence Banks; Vjekoslav Tomaić
Journal:  J Virol       Date:  2019-12-12       Impact factor: 5.103

3.  PDZRN3/LNX3 is a novel target of human papillomavirus type 16 (HPV-16) and HPV-18 E6.

Authors:  Miranda Thomas; Lawrence Banks
Journal:  J Virol       Date:  2014-10-29       Impact factor: 5.103

4.  Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.

Authors:  Siaw Shi Boon; Vjekoslav Tomaić; Miranda Thomas; Sally Roberts; Lawrence Banks
Journal:  J Virol       Date:  2014-11-19       Impact factor: 5.103

5.  Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization.

Authors:  Sydney Webb Strickland; Nicole Brimer; Charles Lyons; Scott B Vande Pol
Journal:  Virology       Date:  2018-01-12       Impact factor: 3.616

Review 6.  Host cell restriction factors that limit transcription and replication of human papillomavirus.

Authors:  Samuel S Porter; Wesley H Stepp; James D Stamos; Alison A McBride
Journal:  Virus Res       Date:  2016-11-15       Impact factor: 3.303

7.  Loss of the E6AP Ubiquitin Ligase Induces p53-Dependent Phosphorylation of Human Papillomavirus 18 E6 in Cells Derived from Cervical Cancer.

Authors:  Arushi Vats; Neva Skrabar; Giannino Del Sal; Lawrence Banks
Journal:  J Virol       Date:  2022-01-19       Impact factor: 6.549

Review 8.  The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.

Authors:  Ketaki Ganti; Justyna Broniarczyk; Wiem Manoubi; Paola Massimi; Suruchi Mittal; David Pim; Anita Szalmas; Jayashree Thatte; Miranda Thomas; Vjekoslav Tomaić; Lawrence Banks
Journal:  Viruses       Date:  2015-07-02       Impact factor: 5.048

Review 9.  The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle.

Authors:  Caleb C McKinney; Katherine L Hussmann; Alison A McBride
Journal:  Viruses       Date:  2015-05-21       Impact factor: 5.048

10.  Potential implications of GRP58 expression and susceptibility of cervical cancer to cisplatin and thymoquinone-based therapy.

Authors:  Wan Abd Ghani Wan Nor Hafiza; Saiful Yazan Latifah
Journal:  Onco Targets Ther       Date:  2014-08-07       Impact factor: 4.147
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.