| Literature DB >> 24352002 |
Kosuke Tanaka1, Chikashi Terao1, Koichiro Ohmura2, Meiko Takahashi1, Ran Nakashima2, Yoshitaka Imura2, Hajime Yoshifuji2, Naoichiro Yukawa2, Takashi Usui2, Takao Fujii2, Tsuneyo Mimori2, Fumihiko Matsuda1.
Abstract
Although the association between CYP3A5 polymorphism and blood concentration of tacrolimus (TAC) in patients with solid organ transplantation was established, whether the association is also true in patients with connective tissue disease (CTD) who usually receive small amount of TAC is uncertain. Here, we performed a quantitative linear regression analysis to address the association between CYP3A5 and blood TAC concentration in patients with CTD. A total of 72 patients with CTD were recruited in the current study and genotyped for rs776746 in CYP3A5, which showed strong association with TAC concentration in patients with solid organ transplantation. The blood trough concentration of TAC after taking 3 mg per day was retrospectively obtained for each patient. As a result, allele A of rs776746 showed a significant association with a decreasing blood concentration of TAC (P=0.0038). Those who are carrying at least one copy of the A allele displayed decreased mean concentration of TAC by 31.0% compared with subjects with GG genotype. Rs776746 is associated with concentrations of TAC in patients with CTD.Entities:
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Year: 2013 PMID： 24352002 DOI： 10.1038/jhg.2013.129
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172