Mirthe E van der Valk1, Marie-Josée J Mangen2, Max Leenders1, Gerard Dijkstra3, Ad A van Bodegraven4, Herma H Fidder1, Dirk J de Jong5, Marieke Pierik6, C Janneke van der Woude7, Mariëlle J L Romberg-Camps8, Cees H M Clemens9, Jeroen M Jansen10, Nofel Mahmmod11, Paul C van de Meeberg12, Andrea E van der Meulen-de Jong13, Cyriel Y Ponsioen14, Clemens J M Bolwerk15, J Reinoud Vermeijden16, Peter D Siersema1, Martijn G H van Oijen17, Bas Oldenburg18. 1. Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands. 2. Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands. 3. Department of Gastroenterology and Hepatology, University Medical Centre Groningen, Groningen, The Netherlands. 4. Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands. 5. Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. 6. Department of Gastroenterology and Hepatology, Maastricht University Medical Centre, Maastricht, The Netherlands. 7. Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands. 8. Department of Gastroenterology and Hepatology, Orbis Medical Centre, Sittard, The Netherlands. 9. Department of Gastroenterology and Hepatology, Diaconessenhuis, Leiden, The Netherlands. 10. Department of Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands. 11. Department of Gastroenterology and Hepatology, Antonius Hospital, Nieuwegein, The Netherlands. 12. Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, The Netherlands. 13. Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands. 14. Department of Gastroenterology and Hepatology, Academic Medical Centre Amsterdam, The Netherlands. 15. Department of Gastroenterology and Hepatology, Reinier de Graaf Groep, Delft, The Netherlands. 16. Department of Gastroenterology and Hepatology, Meander Medical Centre, Amersfoort, The Netherlands. 17. Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands; Division of Digestive Diseases, David Geffen School of Medicine at University of California, Los Angeles, United States. 18. Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands. Electronic address: boldenbu@umcutrecht.nl.
Abstract
BACKGROUND: Inflammatory bowel disease (IBD) is associated with high costs to society. Few data on the impact of IBD on work disability and potential predictive factors are available. AIM: To assess the prevalence of and predictive factors for work disability in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: A web-based questionnaire was sent out in seven university hospitals and seven general hospitals in the Netherlands. Initially, 3050 adult IBD patients were included in this prospective, nationwide cohort study, whereof 2629 patients were within the working-age (18-64 years). We used the baseline questionnaire to assess the prevalence rates of work disability in CD and UC patients within working-age. Prevalence rates were compared with the Dutch background population using age- and sex-matched data obtained from Statistics Netherlands. Multivariable logistic regression analyses were performed to identify independent demographic- and disease-specific risk factors for work disability. RESULTS: In CD, 18.3% of patients was fully disabled and 8.8% partially disabled, compared to 9.5% and 5.4% in UC patients (p<0.01), respectively. Compared to Dutch controls, the prevalence was significantly higher, especially in CD patients. Higher age, low education, depression, chronic back pain, joint manifestations and typical disease-related risk factors such as penetrating disease course and surgery in the past were all found to be associated with work disability. CONCLUSION: We report high work disability rates in a large sample of IBD patients in the Netherlands. CD patients suffer more frequently from work disability than UC patients. A combination of demographic and disease-related factors is predictive of work disability.
BACKGROUND:Inflammatory bowel disease (IBD) is associated with high costs to society. Few data on the impact of IBD on work disability and potential predictive factors are available. AIM: To assess the prevalence of and predictive factors for work disability in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: A web-based questionnaire was sent out in seven university hospitals and seven general hospitals in the Netherlands. Initially, 3050 adult IBDpatients were included in this prospective, nationwide cohort study, whereof 2629 patients were within the working-age (18-64 years). We used the baseline questionnaire to assess the prevalence rates of work disability in CD and UC patients within working-age. Prevalence rates were compared with the Dutch background population using age- and sex-matched data obtained from Statistics Netherlands. Multivariable logistic regression analyses were performed to identify independent demographic- and disease-specific risk factors for work disability. RESULTS: In CD, 18.3% of patients was fully disabled and 8.8% partially disabled, compared to 9.5% and 5.4% in UC patients (p<0.01), respectively. Compared to Dutch controls, the prevalence was significantly higher, especially in CDpatients. Higher age, low education, depression, chronic back pain, joint manifestations and typical disease-related risk factors such as penetrating disease course and surgery in the past were all found to be associated with work disability. CONCLUSION: We report high work disability rates in a large sample of IBDpatients in the Netherlands. CDpatients suffer more frequently from work disability than UC patients. A combination of demographic and disease-related factors is predictive of work disability.
Authors: Renata de S B Fróes; Ana Teresa Pugas Carvalho; Antonio Jose de V Carneiro; Adriana Maria Hilu de Barros Moreira; Jessica P L Moreira; Ronir R Luiz; Heitor S de Souza Journal: Eur J Health Econ Date: 2017-05-18
Authors: L Peyrin-Biroulet; W Sandborn; B E Sands; W Reinisch; W Bemelman; R V Bryant; G D'Haens; I Dotan; M Dubinsky; B Feagan; G Fiorino; R Gearry; S Krishnareddy; P L Lakatos; E V Loftus; P Marteau; P Munkholm; T B Murdoch; I Ordás; R Panaccione; R H Riddell; J Ruel; D T Rubin; M Samaan; C A Siegel; M S Silverberg; J Stoker; S Schreiber; S Travis; G Van Assche; S Danese; J Panes; G Bouguen; S O'Donnell; B Pariente; S Winer; S Hanauer; J-F Colombel Journal: Am J Gastroenterol Date: 2015-08-25 Impact factor: 10.864
Authors: Michael D Mandel; Mandel D Michael; Anita Bálint; Barbara D Lovász; László Gulácsi; Bálint Strbák; Petra A Golovics; Klaudia Farkas; Zsuzsanna Kürti; Blanka K Szilágyi; Anna Mohás; Tamás Molnár; Péter L Lakatos Journal: Eur J Health Econ Date: 2014-05-16
Authors: Niels Teich; Michael Bläker; Frank Holtkamp-Endemann; Eric Jörgensen; Andreas Stallmach; Susanne Hohenberger Journal: Inflamm Intest Dis Date: 2020-12-18
Authors: Åsa H Everhov; Gustaf Bruze; Jonas Söderling; Johan Askling; Jonas Halfvarson; Karin Westberg; Petter Malmborg; Caroline Nordenvall; Jonas F Ludvigsson; Ola Olén Journal: J Crohns Colitis Date: 2021-06-22 Impact factor: 9.071