Garnett P McMillan1, Timothy E Hanson. 1. 1VA RR&D National Center for Rehabilitative Auditory Research (NCRAR), Portland VA, Medical Center, Portland, Oregon, USA; 2Oregon Health and Science University, Department of Public Health and Preventive Medicine, Portland, Oregon, USA; and 3Department of Statistics, University of South Carolina, 216 LeConte College Columbia, South Carolina, USA.
Abstract
OBJECTIVE: To define sample size requirements for establishing clinical serial monitoring protocols. DESIGN: The 95% confidence bound of a critical difference score is defined and used to identify false-negative regions suitable for sample size calculation. RESULTS: Reference subject sample sizes vary from about 40 to 480 subjects, depending on the minimum acceptable error rates of the clinical protocol. CONCLUSIONS: Sample size requirements for establishing test-retest standards are generally defined and suitable for any serial monitoring protocol.
OBJECTIVE: To define sample size requirements for establishing clinical serial monitoring protocols. DESIGN: The 95% confidence bound of a critical difference score is defined and used to identify false-negative regions suitable for sample size calculation. RESULTS: Reference subject sample sizes vary from about 40 to 480 subjects, depending on the minimum acceptable error rates of the clinical protocol. CONCLUSIONS: Sample size requirements for establishing test-retest standards are generally defined and suitable for any serial monitoring protocol.
Authors: Dawn Konrad-Martin; Kristin Knight; Garnett P McMillan; Laura E Dreisbach; Elsa Nelson; Marilyn Dille Journal: Ear Hear Date: 2020 Mar/Apr Impact factor: 3.570