PURPOSE: The comparison of cell lines with differing radiosensitivities and their molecular response to radiation exposure has been used in a number of human cancer models to study the molecular response to radiation. This review proposes to analyze and compare the protocols used by investigators for the development and validation of these isogenic models of radioresistance. CONCLUSION: There is large variability in the strategies used to generate and validate isogenic models of radioresistance. Further characterization of these models is required.
PURPOSE: The comparison of cell lines with differing radiosensitivities and their molecular response to radiation exposure has been used in a number of humancancer models to study the molecular response to radiation. This review proposes to analyze and compare the protocols used by investigators for the development and validation of these isogenic models of radioresistance. CONCLUSION: There is large variability in the strategies used to generate and validate isogenic models of radioresistance. Further characterization of these models is required.
Authors: Georg Emons; Melanie Spitzner; Sebastian Reineke; Janneke Möller; Noam Auslander; Frank Kramer; Yue Hu; Tim Beissbarth; Hendrik A Wolff; Margret Rave-Fränk; Elisabeth Heßmann; Jochen Gaedcke; B Michael Ghadimi; Steven A Johnsen; Thomas Ried; Marian Grade Journal: Mol Cancer Res Date: 2017-08-15 Impact factor: 5.852
Authors: N McDermott; A Meunier; B Mooney; G Nortey; C Hernandez; S Hurley; N Lynam-Lennon; S H Barsoom; K J Bowman; B Marples; G D D Jones; L Marignol Journal: Sci Rep Date: 2016-10-05 Impact factor: 4.379
Authors: Isidro X Perez-Añorve; Claudia H Gonzalez-De la Rosa; Ernesto Soto-Reyes; Fredy O Beltran-Anaya; Oscar Del Moral-Hernandez; Marisol Salgado-Albarran; Oscar Angeles-Zaragoza; Juan A Gonzalez-Barrios; Daniel A Landero-Huerta; Margarita Chavez-Saldaña; Alejandro Garcia-Carranca; Nicolas Villegas-Sepulveda; Elena Arechaga-Ocampo Journal: Mol Oncol Date: 2019-04-18 Impact factor: 6.603