Literature DB >> 24349631

Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.

Ajay Rana1, Basabi Rana2, Rajakishore Mishra3, Gautam Sondarva4, Velusamy Rangasamy5, Subhasis Das4, Navin Viswakarma4, Anumantha Kanthasamy6.   

Abstract

Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are yet unknown. However, MLKs in general have been implicated in neurodegenerative diseases, including Parkinson and Alzheimer diseases. Recent reports suggest that some of the MLK members could play a role in cancer via modulating cell migration, invasion, cell cycle, and apoptosis. This review article will first describe the biology of MLK members and then discuss the current progress that relates to their functions in cancer.

Entities:  

Keywords:  JNK; MAPKs; MLKs; cancer; phosphorylation

Year:  2013        PMID： 24349631      PMCID： PMC3863337          DOI： 10.1177/1947601913485415

Source DB:  PubMed          Journal:  Genes Cancer        ISSN： 1947-6019


  48 in total

Review 1.  Structure and regulation of Src family kinases.

Authors:  Titus J Boggon; Michael J Eck
Journal:  Oncogene       Date:  2004-10-18       Impact factor: 9.867

2.  Mixed lineage kinase 3 modulates β-catenin signaling in cancer cells.

Authors:  Ramesh P Thylur; Subramanian Senthivinayagam; Edward M Campbell; Velusamy Rangasamy; Nithyananda Thorenoor; Gautam Sondarva; Suneet Mehrotra; Prajna Mishra; Erin Zook; Phong T Le; Ajay Rana; Basabi Rana
Journal:  J Biol Chem       Date:  2011-08-31       Impact factor: 5.157

3.  Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling.

Authors:  Pradeep Sathyanarayana; Manoj K Barthwal; Mary Ellen Lane; Summer F Acevedo; Efthimios M C Skoulakis; Andreas Bergmann; Ajay Rana
Journal:  Biochim Biophys Acta       Date:  2003-04-07

4.  MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis.

Authors:  Jian Chen; Kathleen A Gallo
Journal:  Cancer Res       Date:  2012-06-13       Impact factor: 12.701

Review 5.  The JNK signal transduction pathway.

Authors:  Claire R Weston; Roger J Davis
Journal:  Curr Opin Genet Dev       Date:  2002-02       Impact factor: 5.578

6.  The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

Authors:  A Rana; K Gallo; P Godowski; S Hirai; S Ohno; L Zon; J M Kyriakis; J Avruch
Journal:  J Biol Chem       Date:  1996-08-09       Impact factor: 5.157

7.  Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.

Authors:  Rajakishore Mishra; Manoj K Barthwal; Gautam Sondarva; Basabi Rana; Lucas Wong; Malay Chatterjee; James R Woodgett; Ajay Rana
Journal:  J Biol Chem       Date:  2007-08-21       Impact factor: 5.157

8.  Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3.

Authors:  I W Leung; N Lassam
Journal:  J Biol Chem       Date:  1998-12-04       Impact factor: 5.157

9.  PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase.

Authors:  Luc Poitras; Steve Jean; Nazrul Islam; Tom Moss
Journal:  FEBS Lett       Date:  2003-05-22       Impact factor: 4.124

10.  TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation.

Authors:  Gautam Sondarva; Chanakya N Kundu; Suneet Mehrotra; Rajakishore Mishra; Velusamy Rangasamy; Pradeep Sathyanarayana; Rajarshi S Ray; Basabi Rana; Ajay Rana
Journal:  Cell Res       Date:  2009-11-17       Impact factor: 25.617
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  14 in total

1.  Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival.

Authors:  Subhasis Das; Gautam Sondarva; Navin Viswakarma; Rakesh Sathish Nair; Clodia Osipo; Guri Tzivion; Basabi Rana; Ajay Rana
Journal:  J Biol Chem       Date:  2015-07-07       Impact factor: 5.157

2.  Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.

Authors:  Bradley Garman; Ioannis N Anastopoulos; Clemens Krepler; Patricia Brafford; Katrin Sproesser; Yuchao Jiang; Bradley Wubbenhorst; Ravi Amaravadi; Joseph Bennett; Marilda Beqiri; David Elder; Keith T Flaherty; Dennie T Frederick; Tara C Gangadhar; Michael Guarino; David Hoon; Giorgos Karakousis; Qin Liu; Nandita Mitra; Nicholas J Petrelli; Lynn Schuchter; Batool Shannan; Carol L Shields; Jennifer Wargo; Brandon Wenz; Melissa A Wilson; Min Xiao; Wei Xu; Xaiowei Xu; Xiangfan Yin; Nancy R Zhang; Michael A Davies; Meenhard Herlyn; Katherine L Nathanson
Journal:  Cell Rep       Date:  2017-11-14       Impact factor: 9.423

3.  Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2+ breast cancer by ceramide-loaded nanoparticles.

Authors:  Sandeep Kumar; Subhasis Das; Jingjing Sun; Yixian Huang; Sunil Kumar Singh; Piush Srivastava; Gautam Sondarva; Rakesh Sathish Nair; Navin Viswakarma; Balaji B Ganesh; Lei Duan; Carl G Maki; Kent Hoskins; Oana Danciu; Basabi Rana; Song Li; Ajay Rana
Journal:  Proc Natl Acad Sci U S A       Date:  2022-09-12       Impact factor: 12.779

4.  Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development.

Authors:  Navin Viswakarma; Gautam Sondarva; Daniel R Principe; Rakesh Sathish Nair; Sandeep Kumar; Sunil Kumar Singh; Subhasis Das; Subhash C Sinha; Paul J Grippo; Sam Grimaldo; Pier Cristoforo Giulianotti; Basabi Rana; Ajay Rana
Journal:  Cancer Lett       Date:  2021-05-27       Impact factor: 9.756

5.  MLK3 phophorylates AMPK independently of LKB1.

Authors:  Lingyu Luo; Shanshan Jiang; Deqiang Huang; Nonghua Lu; Zhijun Luo
Journal:  PLoS One       Date:  2015-04-13       Impact factor: 3.240

6.  Overexpression of C-terminal fragment of glutamate receptor 6 prevents neuronal injury in kainate-induced seizure via disassembly of GluR6-PSD-95-MLK3 signaling module.

Authors:  Jie Mou; Xiaomei Liu; Dongsheng Pei
Journal:  Neural Regen Res       Date:  2014-12-01       Impact factor: 5.135

7.  Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model.

Authors:  Kun Hyoe Rhoo; Megan Granger; Joynita Sur; Changyong Feng; Harris A Gelbard; Stephen Dewhurst; Oksana Polesskaya
Journal:  PLoS One       Date:  2014-09-29       Impact factor: 3.240

8.  Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesis.

Authors:  Navin Viswakarma; Rakesh Sathish Nair; Gautam Sondarva; Subhasis Das; Lucas Ibrahimi; Zhiyong Chen; Subhash Sinha; Basabi Rana; Ajay Rana
Journal:  Oncotarget       Date:  2017-05-16

9.  Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.

Authors:  Sandeep Kumar; Sunil Kumar Singh; Navin Viswakarma; Gautam Sondarva; Rakesh Sathish Nair; Periannan Sethupathi; Subhash C Sinha; Rajyasree Emmadi; Kent Hoskins; Oana Danciu; Gregory R J Thatcher; Basabi Rana; Ajay Rana
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-24       Impact factor: 12.779

Review 10.  MLK3 Signaling in Cancer Invasion.

Authors:  Chotirat Rattanasinchai; Kathleen A Gallo
Journal:  Cancers (Basel)       Date:  2016-05-19       Impact factor: 6.639
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