Literature DB >> 24348685

TSLP: A Key Regulator of Asthma Pathogenesis.

Erin E West1, Mohit Kashyap1, Warren J Leonard1.   

Abstract

Asthma is a complex disorder of the airways that is characterized by T helper type 2 (Th2) inflammation. The pleiotrophic cytokine TSLP has emerged as an important player involved in orchestrating the inflammation seen in asthma and other atopic diseases. Early research elucidated the role of TSLP on CD4+ T cells, and recent work has revealed the impact of TSLP on multiple cell types. Furthermore, TSLP plays an important role in the sequential progression of atopic dermatitis to asthma, clarifying the key role of TSLP in the pathogenesis of asthma, a finding with therapeutic implications.

Entities:  

Year:  2012        PMID： 24348685      PMCID： PMC3859144          DOI： 10.1016/j.ddmec.2012.09.003

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  53 in total

Review 1.  TSLP expression: cellular sources, triggers, and regulatory mechanisms.

Authors:  Toshiro Takai
Journal:  Allergol Int       Date:  2012-01-25       Impact factor: 5.836

Review 2.  Innate and adaptive immune responses in asthma.

Authors:  Stephen T Holgate
Journal:  Nat Med       Date:  2012-05-04       Impact factor: 53.440

3.  Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma.

Authors:  Lena Uller; Marina Leino; Nicole Bedke; David Sammut; Ben Green; Laurie Lau; Peter H Howarth; Stephen T Holgate; Donna E Davies
Journal:  Thorax       Date:  2010-07       Impact factor: 9.139

4.  Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.

Authors:  Sun Ying; Brian O'Connor; Jonathan Ratoff; Qiu Meng; Kirsty Mallett; David Cousins; Douglas Robinson; Guizhen Zhang; Jisheng Zhao; Tak H Lee; Chris Corrigan
Journal:  J Immunol       Date:  2005-06-15       Impact factor: 5.422

5.  dsRNA-induced expression of thymic stromal lymphopoietin (TSLP) in asthmatic epithelial cells is inhibited by a small airway relaxant.

Authors:  Angelica Brandelius; Yulyana Yudina; Jenny Calvén; Leif Bjermer; Morgan Andersson; Carl Persson; Lena Uller
Journal:  Pulm Pharmacol Ther       Date:  2010-10-14       Impact factor: 3.410

6.  Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

Authors:  Renata Mazzucchelli; Julie A Hixon; Rosanne Spolski; Xin Chen; Wen Qing Li; Veronica L Hall; Jami Willette-Brown; Arthur A Hurwitz; Warren J Leonard; Scott K Durum
Journal:  Blood       Date:  2008-07-29       Impact factor: 22.113

7.  Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma.

Authors:  H Han; W Xu; M B Headley; H K Jessup; K S Lee; M Omori; M R Comeau; A Marshak-Rothstein; S F Ziegler
Journal:  Mucosal Immunol       Date:  2012-02-22       Impact factor: 7.313

8.  TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.

Authors:  Tomoki Ito; Yui-Hsi Wang; Omar Duramad; Toshiyuki Hori; Guy J Delespesse; Norihiko Watanabe; F Xiao-Feng Qin; Zhengbin Yao; Wei Cao; Yong-Jun Liu
Journal:  J Exp Med       Date:  2005-11-07       Impact factor: 14.307

9.  A role for TSLP in the development of inflammation in an asthma model.

Authors:  Amin Al-Shami; Rosanne Spolski; John Kelly; Andrea Keane-Myers; Warren J Leonard
Journal:  J Exp Med       Date:  2005-09-19       Impact factor: 14.307

10.  MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

Authors:  Jacqueline G Perrigoue; Steven A Saenz; Mark C Siracusa; Eric J Allenspach; Betsy C Taylor; Paul R Giacomin; Meera G Nair; Yurong Du; Colby Zaph; Nico van Rooijen; Michael R Comeau; Edward J Pearce; Terri M Laufer; David Artis
Journal:  Nat Immunol       Date:  2009-05-24       Impact factor: 25.606
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  14 in total

Review 1.  Pediatric Eosinophilic Esophagitis Endotypes: Are We Closer to Predicting Treatment Response?

Authors:  Anna E Ferguson; Vince A Mukkada; Patricia C Fulkerson
Journal:  Clin Rev Allergy Immunol       Date:  2018-08       Impact factor: 8.667

Review 2.  Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis.

Authors:  Maho Nagasawa; Hergen Spits; Xavier Romero Ros
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-12-03       Impact factor: 10.005

3.  Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease.

Authors:  Cheryl van de Wetering; Reem Aboushousha; Allison M Manuel; Shi B Chia; Cuixia Erickson; Maximilian B MacPherson; Jos L van der Velden; Vikas Anathy; Anne E Dixon; Charles G Irvin; Matthew E Poynter; Albert van der Vliet; Emiel F M Wouters; Niki L Reynaert; Yvonne M W Janssen-Heininger
Journal:  J Immunol       Date:  2020-01-10       Impact factor: 5.422

4.  Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma.

Authors:  Luciana N García; Carolina Leimgruber; Elisa M Uribe Echevarría; Patricio L Acosta; Jorge M Brahamian; Fernando P Polack; María S Miró; Amado A Quintar; Claudia E Sotomayor; Cristina A Maldonado
Journal:  Exp Biol Med (Maywood)       Date:  2014-12-11

Review 5.  Key mediators in the immunopathogenesis of allergic asthma.

Authors:  Sannette Hall; Devendra K Agrawal
Journal:  Int Immunopharmacol       Date:  2014-06-13       Impact factor: 4.932

6.  Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes.

Authors:  Christopher S Thom; Benjamin F Voight
Journal:  BMC Med Genomics       Date:  2020-06-29       Impact factor: 3.063

7.  Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation.

Authors:  Yun-Han Weng; Wei-Yu Chen; Yen-Lin Lin; Jiu-Yao Wang; Ming-Shi Chang
Journal:  Front Immunol       Date:  2019-04-30       Impact factor: 7.561

8.  Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection.

Authors:  Youxian Li; Cecilie Lund; Ida Nervik; Simon Loevenich; Henrik Døllner; Marit W Anthonsen; Ingvild B Johnsen
Journal:  Sci Rep       Date:  2018-01-17       Impact factor: 4.379

9.  A tumor-myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer.

Authors:  Emma L Kuan; Steven F Ziegler
Journal:  Nat Immunol       Date:  2018-03-19       Impact factor: 25.606

10.  Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.

Authors:  Santosh K Mishra; Joshua J Wheeler; Saumitra Pitake; Huiping Ding; Changyu Jiang; Tomoki Fukuyama; Judy S Paps; Patrick Ralph; Jacob Coyne; Michelle Parkington; Jennifer DeBrecht; Lauren C Ehrhardt-Humbert; Glenn P Cruse; Wolfgang Bäumer; Ru-Rong Ji; Mei-Chuan Ko; Thierry Olivry
Journal:  Cell Rep       Date:  2020-04-07       Impact factor: 9.995
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