| Literature DB >> 24346948 |
Yun-Lin Liu1, Xin Wang, Yu-Lei Zhao, Feng Zhu, Xing-Ping Zeng, Long Chen, Cui-Hong Wang, Xiao-Li Zhao, Jian Zhou.
Abstract
All in a sequence: An organocatalyzed Morita-Baylis-Hillman (MBH)/bromination/[3+2] annulation sequence for highly stereoselective syntheses of bis(spirooxindole)s featuring adjacent spiro-stereocenters is described. The key step is an unprecedented catalytic asymmetric [3+2] annulation of isatin-derived MBH adducts, containing a tetrasubstituted alkene moiety, with isatins.Entities:
Keywords: asymmetric catalysis; heterocycles; organocatalysis; spiro compounds; synthetic methods
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Year: 2013 PMID： 24346948 DOI： 10.1002/anie.201307250
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336