Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane.

Literature DB >> 24346146

Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane.

Daniel Hofmann¹, Claudia Messerschmidt, Markus B Bannwarth, Katharina Landfester, Volker Mailänder.

Abstract

Nearly all concepts of nanocarriers as drug delivery devices rely on intracellular uptake. Instead, we demonstrate an alternative concept for rapid and specific delivery of cargo by nanoparticles to TIP47+/ADRP+ lipid droplets. The model can serve as a novel strategy for the non-invasive delivery of drugs by releasing hydrophobic cargo, in our case a model dye, through a kiss-and-run mechanism between nanoparticles and the cell membrane.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2014 PMID： 24346146 DOI： 10.1039/c3cc48130a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

Keyword Cloud
Cited

11 in total

1. Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy.

Authors: Ivan S Alferiev; Radhika Iyer; Jamie L Croucher; Richard F Adamo; Kehan Zhang; Jennifer L Mangino; Venkatadri Kolla; Ilia Fishbein; Garrett M Brodeur; Robert J Levy; Michael Chorny
Journal: Biomaterials Date: 2015-02-16 Impact factor: 12.479

2. Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores.

Authors: Ivan S Alferiev; Ilia Fishbein; Robert J Levy; Michael Chorny
Journal: ACS Appl Polym Mater Date: 2022-01-06

3. Dual Mass Spectrometric Tissue Imaging of Nanocarrier Distributions and Their Biochemical Effects.

Authors: Kristen N Sikora; Joseph M Hardie; Laura J Castellanos-García; Yuanchang Liu; Biidaaban M Reinhardt; Michelle E Farkas; Vincent M Rotello; Richard W Vachet
Journal: Anal Chem Date: 2019-12-30 Impact factor: 6.986

4. Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation.

Authors: Federica De Gaetano; Maria Chiara Cristiano; Valentina Venuti; Vincenza Crupi; Domenico Majolino; Giuseppe Paladini; Giuseppe Acri; Barbara Testagrossa; Alessia Irrera; Donatella Paolino; Silvana Tommasini; Cinzia Anna Ventura; Rosanna Stancanelli
Journal: Molecules Date: 2021-02-16 Impact factor: 4.411

Review 10. Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles.

Authors: Zhe Chen; Yuanqiang Zheng; Yanchun Shi; Zhengrong Cui
Journal: Int J Nanomedicine Date: 2018-01-09

Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane.

1. Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy.

2. Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores.

3. Dual Mass Spectrometric Tissue Imaging of Nanocarrier Distributions and Their Biochemical Effects.

4. Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation.

5. Nanodelivery vehicles induce remote biochemical changes in vivo.

6. Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles.

7. Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues.

8. Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates.

9. Cell adherence and drug delivery from particle based mesoporous silica films.

Review 10. Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles.