M Effendi1, S Demers2, Y Giguère3, J-C Forest3, N Brassard4, M Girard5, K Gouin4, E Bujold6. 1. Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada. 2. Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Québec, QC, Canada; Department of Obstetrics & Gynaecology, Faculty of Medicine, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC, Canada. 3. Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec, QC, Canada; Centre de recherche du Centre Hospitalier, Universitaire de Québec, Québec, QC, Canada. 4. Department of Obstetrics & Gynaecology, Faculty of Medicine, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC, Canada. 5. Centre de recherche du Centre Hospitalier, Universitaire de Québec, Québec, QC, Canada. 6. Department of Obstetrics & Gynaecology, Faculty of Medicine, Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC, Canada; Centre de recherche du Centre Hospitalier, Universitaire de Québec, Québec, QC, Canada. Electronic address: emmanuel.bujold@crchul.ulaval.ca.
Abstract
OBJECTIVE: To estimate the correlation between first-trimester placental volume, birth weight, small-for-gestational-age (SGA), and preeclampsia. METHODS: A prospective study of women with singleton pregnancy at 11-13 weeks of gestation was conducted. First-trimester placental volume was measured using three-dimensional ultrasound and reported as multiple of median (MoM) for gestational age. Participants were followed until delivery where birth weight, placental weight, and occurrence of preeclampsia were collected. Non-parametric analyses were performed. RESULTS: We reached a complete follow-up for 543 eligible women. First-trimester placental volume was significantly correlated with birth weight (correlation coefficient: 0.18; p < 0.0001) and placental weight (cc: 0.22; p < 0.0001) adjusted for gestational age. First-trimester placental volume was smaller in women who delivered SGA neonates (median MoM: 0.79; interquartile range: 0.62-1.00; p < 0.001) and greater in women who delivered large-for-gestational-age neonates (median MoM: 1.13; 0.95-1.49; p < 0.001) when compared to women with neonates between the 10th and 90th percentile (median MoM: 1.00; 0.81-1.25). First-trimester placental volume was not associated with the risk of preeclampsia (cc: 0.01; p = 0.87). CONCLUSION: First-trimester placental volume is strongly associated with fetal and placental growth. However, we did not observe a correlation between placental volume and the risk of preeclampsia.
OBJECTIVE: To estimate the correlation between first-trimester placental volume, birth weight, small-for-gestational-age (SGA), and preeclampsia. METHODS: A prospective study of women with singleton pregnancy at 11-13 weeks of gestation was conducted. First-trimester placental volume was measured using three-dimensional ultrasound and reported as multiple of median (MoM) for gestational age. Participants were followed until delivery where birth weight, placental weight, and occurrence of preeclampsia were collected. Non-parametric analyses were performed. RESULTS: We reached a complete follow-up for 543 eligible women. First-trimester placental volume was significantly correlated with birth weight (correlation coefficient: 0.18; p < 0.0001) and placental weight (cc: 0.22; p < 0.0001) adjusted for gestational age. First-trimester placental volume was smaller in women who delivered SGA neonates (median MoM: 0.79; interquartile range: 0.62-1.00; p < 0.001) and greater in women who delivered large-for-gestational-age neonates (median MoM: 1.13; 0.95-1.49; p < 0.001) when compared to women with neonates between the 10th and 90th percentile (median MoM: 1.00; 0.81-1.25). First-trimester placental volume was not associated with the risk of preeclampsia (cc: 0.01; p = 0.87). CONCLUSION: First-trimester placental volume is strongly associated with fetal and placental growth. However, we did not observe a correlation between placental volume and the risk of preeclampsia.
Authors: N Andescavage; A duPlessis; M Metzler; D Bulas; G Vezina; M Jacobs; S N Iqbal; A Baschat; C Limperopoulos Journal: J Perinatol Date: 2017-08-24 Impact factor: 2.521
Authors: S J Woolford; E M Curtis; S D'Angelo; P Mahon; L Cooke; J K Cleal; S R Crozier; K M Godfrey; H M Inskip; C Cooper; N C Harvey Journal: Placenta Date: 2020-07-22 Impact factor: 3.481
Authors: Linette van Duijn; Melek Rousian; Igna F Reijnders; Sten P Willemsen; Esther B Baart; Joop S E Laven; Régine P M Steegers-Theunissen Journal: Hum Reprod Date: 2021-07-19 Impact factor: 6.918