Literature DB >> 24344902

Patient satisfaction with testosterone replacement therapies: the reasons behind the choices.

Jason R Kovac1, Saneal Rajanahally, Ryan P Smith, Robert M Coward, Dolores J Lamb, Larry I Lipshultz.   

Abstract

INTRODUCTION: Testosterone replacement therapy (TRT) for male hypogonadism is rapidly gaining popularity and acceptance. Options include gels, injections, and implantable subcutaneous pellets. AIMS: The aim of this study was to determine rates of patient satisfaction and reasons for patient preferences in hypogonadal men on TRT.
METHODS: An anonymous, prospective survey was distributed to men presenting for TRT at an academic urology clinic. The survey was organized into multiple domains including patient satisfaction and treatment motivation. MAIN OUTCOME MEASURES: Patient satisfaction responses obtained via anonymous survey.
RESULTS: Average patient age was 49 ± 0.7 years (n = 382). Injectable testosterone was chosen by 53%, gel-based regimens by 31%, and pellets by 17%. Overall, 70% of patients were satisfied with their TRT and 14% reported dissatisfaction. Satisfaction rates were similar between gels (68%), injections (73%), and implantable pellets (70%). Doctor recommendation was the sole significant reason for patients preferring gel-based TRT (66% vs. 37% injection users vs. 31% pellet users). Injectable TRT was favored because of lower cost (35% vs. 21% gel users vs. 19% pellet users). Pellets were favored for ease of use (64% vs. 44% injection users vs. 43% gel users) and convenience (58% vs. 26% injection users vs. 19% gel users). Pellets had increased rates of satisfaction within the first 12 months. Improvements in concentration and mood occurred at higher percentages in satisfied patients.
CONCLUSIONS: Patients are satisfied with TRT. Lower costs are important to patients on injections. Convenience and ease of use are central in choosing pellet therapy. Men on TRT should be questioned about mood and concentration because these factors exhibited the greatest improvements in satisfied patients.
© 2013 International Society for Sexual Medicine.

Entities:  

Keywords:  Male Hypogonadism; Patient Preferences; Patient Satisfaction; Testosterone Replacement Therapy

Mesh:

Substances:

Year:  2013        PMID: 24344902      PMCID: PMC3946859          DOI: 10.1111/jsm.12369

Source DB:  PubMed          Journal:  J Sex Med        ISSN: 1743-6095            Impact factor:   3.802


  56 in total

1.  A brief history of testosterone.

Authors:  E R Freeman; D A Bloom; E J McGuire
Journal:  J Urol       Date:  2001-02       Impact factor: 7.450

2.  Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men.

Authors:  Christina Wang; Glenn Cunningham; Adrian Dobs; Ali Iranmanesh; Alvin M Matsumoto; Peter J Snyder; Thomas Weber; Nancy Berman; Laura Hull; Ronald S Swerdloff
Journal:  J Clin Endocrinol Metab       Date:  2004-05       Impact factor: 5.958

Review 3.  The evidence for seasonal variations of testosterone in men.

Authors:  Ryan P Smith; Robert M Coward; Jason R Kovac; Larry I Lipshultz
Journal:  Maturitas       Date:  2013-01-05       Impact factor: 4.342

Review 4.  Treatment options for a patient experiencing pruritic rash associated with transdermal testosterone: a review of the literature.

Authors:  N J McGriff; G Csako; M Kabbani; L Diep; G P Chrousos; F Pucino
Journal:  Pharmacotherapy       Date:  2001-11       Impact factor: 4.705

5.  A multi-institutional observational study of testosterone levels after testosterone pellet (Testopel(®)) insertion.

Authors:  Andrew R McCullough; Mohit Khera; Irwin Goldstein; Wayne J G Hellstrom; Abraham Morgentaler; Laurence A Levine
Journal:  J Sex Med       Date:  2012-01-12       Impact factor: 3.802

6.  Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a phase II study.

Authors:  Sigrid von Eckardstein; Eberhard Nieschlag
Journal:  J Androl       Date:  2002 May-Jun

7.  Efficacy of changing testosterone gel preparations (Androgel or Testim) among suboptimally responsive hypogonadal men.

Authors:  E D Grober; M Khera; S D Soni; M G Espinoza; L I Lipshultz
Journal:  Int J Impot Res       Date:  2007-09-27       Impact factor: 2.896

8.  Testosterone gel monotherapy improves sexual function of hypogonadal men mainly through restoring erection: evaluation by IIEF score.

Authors:  Han-Sun Chiang; Shu-Ling Cho; Yi-Chia Lin; Thomas I S Hwang
Journal:  Urology       Date:  2009-01-01       Impact factor: 2.649

9.  Medication adherence and treatment patterns for hypogonadal patients treated with topical testosterone therapy: a retrospective medical claims analysis.

Authors:  Michael Jay Schoenfeld; Emily Shortridge; Zhanglin Cui; David Muram
Journal:  J Sex Med       Date:  2013-03-06       Impact factor: 3.802

Review 10.  Onset of effects of testosterone treatment and time span until maximum effects are achieved.

Authors:  Farid Saad; Antonio Aversa; Andrea M Isidori; Livia Zafalon; Michael Zitzmann; Louis Gooren
Journal:  Eur J Endocrinol       Date:  2011-07-13       Impact factor: 6.664

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  13 in total

1.  Is semen analysis necessary prior to the commencement of testosterone supplementation therapy in men of reproductive age?

Authors:  Michael Pan; Ranjith Ramasamy; Jason R Kovac
Journal:  Can Urol Assoc J       Date:  2014-11       Impact factor: 1.862

Review 2.  Erythrocytosis Following Testosterone Therapy.

Authors:  Samuel J Ohlander; Bibin Varghese; Alexander W Pastuszak
Journal:  Sex Med Rev       Date:  2017-05-16

Review 3.  Testosterone supplementation therapy in the treatment of patients with metabolic syndrome.

Authors:  Jason R Kovac; Jason Kovac; Alexander W Pastuszak; Dolores J Lamb; Larry I Lipshultz
Journal:  Postgrad Med       Date:  2014-11       Impact factor: 3.840

4.  Trends in testosterone prescription amongst medical specialties: a 5-year CMS data analysis.

Authors:  Isabelle V Carter; Michael J Callegari; Tarun K Jella; Amr Mahran; Thomas B Cwalina; Wade Muncey; Aram Loeb; Nannan Thirumavalavan
Journal:  Int J Impot Res       Date:  2022-01-07       Impact factor: 2.896

5.  A cross-sectional comparison of secondary polycythemia in testosterone-deficient men treated with nasal testosterone gel vs. intramuscular testosterone cypionate.

Authors:  Jordan C Best; Daniel Gonzalez; Thomas A Masterson; Ruben Blachman-Braun; Raghav Pai; Ranjith Ramasamy
Journal:  Can Urol Assoc J       Date:  2021-02       Impact factor: 1.862

6.  A Pilot Study Using a Web Survey to Identify Characteristics That Influence Hypogonadal Men to Initiate Testosterone Replacement Therapy.

Authors:  Raymond C Rosen; Allen D Seftel; Dustin D Ruff; David Muram
Journal:  Am J Mens Health       Date:  2016-01-27

7.  Testosterone Therapy With Subcutaneous Injections: A Safe, Practical, and Reasonable Option.

Authors:  Maria Gabriela Figueiredo; Thiago Gagliano-Jucá; Shehzad Basaria
Journal:  J Clin Endocrinol Metab       Date:  2022-02-17       Impact factor: 5.958

8.  Comparison of the Effects of Testosterone Gels, Injections, and Pellets on Serum Hormones, Erythrocytosis, Lipids, and Prostate-Specific Antigen.

Authors:  Alexander W Pastuszak; Lissette P Gomez; Jason M Scovell; Mohit Khera; Dolores J Lamb; Larry I Lipshultz
Journal:  Sex Med       Date:  2015-08-12       Impact factor: 2.491

Review 9.  A Review of Testosterone Pellets in the Treatment of Hypogonadism.

Authors:  Andrew McCullough
Journal:  Curr Sex Health Rep       Date:  2014

10.  Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single-Use Autoinjector: A Phase II Study.

Authors:  Jed Kaminetsky; Jonathan S Jaffe; Ronald S Swerdloff
Journal:  Sex Med       Date:  2015-09-17       Impact factor: 2.491

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