OBJECTIVE: To assess the association of single nucleotide polymorphisms (SNPs) in five genes - leptin, leptin receptor (LEPR), adiponectin (APM1), peroxisome proliferator-activated receptor gamma (PPARG) and uncoupling protein 1 - with anthropometric, metabolic, and dietary parameters in a Southern Brazilian cohort of 325 children followed up from birth to 4 years old. MATERIALS AND METHODS: SNPs were analyzed using polymerase chain reaction-based procedures, and their association with phenotypes was evaluated by t-test, analysis of variance, and general linear models. RESULTS: LEPR223Arg allele (rs1137101) was associated with higher daily energy intake at 4 years of age (P = 0.002; Pcorrected = 0.024). PPARG 12Ala-carriers (rs1801282) presented higher glucose levels than Pro/Pro homozygotes (P = 0.007; Pcorrected = 0.042). CONCLUSIONS: Two of the six studied SNPs presented consistent associations, showing that it is already possible to detect the influences of genetic variants on susceptibility to overweight in 4-year-old children.
OBJECTIVE: To assess the association of single nucleotide polymorphisms (SNPs) in five genes - leptin, leptin receptor (LEPR), adiponectin (APM1), peroxisome proliferator-activated receptor gamma (PPARG) and uncoupling protein 1 - with anthropometric, metabolic, and dietary parameters in a Southern Brazilian cohort of 325 children followed up from birth to 4 years old. MATERIALS AND METHODS: SNPs were analyzed using polymerase chain reaction-based procedures, and their association with phenotypes was evaluated by t-test, analysis of variance, and general linear models. RESULTS: LEPR223Arg allele (rs1137101) was associated with higher daily energy intake at 4 years of age (P = 0.002; Pcorrected = 0.024). PPARG12Ala-carriers (rs1801282) presented higher glucose levels than Pro/Pro homozygotes (P = 0.007; Pcorrected = 0.042). CONCLUSIONS: Two of the six studied SNPs presented consistent associations, showing that it is already possible to detect the influences of genetic variants on susceptibility to overweight in 4-year-old children.
Authors: E M Queiroz; A P C Cândido; I M Castro; A Q A Bastos; G L L Machado-Coelho; R N Freitas Journal: Braz J Med Biol Res Date: 2015-04-28 Impact factor: 2.590
Authors: Aline Dos Santos Rocha; Rita de Cássia Ribeiro-Silva; Gustavo Nunes de Oliveira Costa; Camila Alexandrina Figueiredo; Laura Cunha Rodrigues; Sheila Maria Alvim Matos; Rosemeire Leovigildo Fiaccone; Pablo Rafael Oliveira; Nadya Helena Alves-Santos; Ronald E Blanton; Maurício Lima Barreto Journal: Nutrients Date: 2018-08-18 Impact factor: 5.717
Authors: Helena Marcos-Pasero; Elena Aguilar-Aguilar; Rocío de la Iglesia; Isabel Espinosa-Salinas; Susana Molina; Gonzalo Colmenarejo; J Alfredo Martínez; Ana Ramírez de Molina; Guillermo Reglero; Viviana Loria-Kohen Journal: Front Nutr Date: 2022-03-08
Authors: Nayera E Hassan; Sahar A El-Masry; Waheba Zarouk; Rokia A El Banna; Rehab M Mosaad; Muhammad Al-Tohamy; Abeer Ramadan Salamah Journal: Genes Dis Date: 2017-12-18