Gyeong-Hun Park1, Sung Eun Chang1, Chong Hyun Won1, Mi Woo Lee2, Jee Ho Choi1, Kee Chan Moon1, Duck Jong Han3, Su Kil Park4, Jae-Joong Kim5, Jae Won Lee6, Sung-Gyu Lee3. 1. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 2. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address: miumiu@amc.seoul.kr. 3. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 4. Department of Nephrology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 5. Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 6. Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Abstract
BACKGROUND: Skin cancer is the most common malignancy to arise after organ transplantation in Caucasians, but limited data are available on its incidence in Asian transplant recipients. OBJECTIVE: We sought to assess the incidence of skin cancer after organ transplantation in a Korean cohort. METHODS: A cohort study was conducted to determine the incidence and risk factors for skin cancers among kidney, liver, heart, or pancreas transplant recipients, treated at the Asan Medical Center in Seoul, Korea. RESULTS: The cumulative incidences of skin cancer were 0.70% at 5 years, 1.66% at 10 years, and 2.31% at 15 years. For all skin cancers, squamous cell carcinoma, basal cell carcinoma, and Kaposi sarcoma, the standardized incidence ratios between the recipients and the Korean general population were 30.9 (95% confidence interval, 12.4-63.6), 61.9 (12.8-180.8), 11.9 (0.3-66.1), and 565.2 (68.4-2041.6) after the end of the fifth posttransplantation year, respectively. LIMITATIONS: We cannot exclude the possibility of both the underestimation because of potential missing cases and the overestimation because of the ascertainment bias. CONCLUSION: The incidence of posttransplantation skin cancer is very low in Korean patients. However, the risk of skin cancer in organ transplant recipients may be considerably higher than that in the Korean general population.
BACKGROUND:Skin cancer is the most common malignancy to arise after organ transplantation in Caucasians, but limited data are available on its incidence in Asian transplant recipients. OBJECTIVE: We sought to assess the incidence of skin cancer after organ transplantation in a Korean cohort. METHODS: A cohort study was conducted to determine the incidence and risk factors for skin cancers among kidney, liver, heart, or pancreas transplant recipients, treated at the Asan Medical Center in Seoul, Korea. RESULTS: The cumulative incidences of skin cancer were 0.70% at 5 years, 1.66% at 10 years, and 2.31% at 15 years. For all skin cancers, squamous cell carcinoma, basal cell carcinoma, and Kaposi sarcoma, the standardized incidence ratios between the recipients and the Korean general population were 30.9 (95% confidence interval, 12.4-63.6), 61.9 (12.8-180.8), 11.9 (0.3-66.1), and 565.2 (68.4-2041.6) after the end of the fifth posttransplantation year, respectively. LIMITATIONS: We cannot exclude the possibility of both the underestimation because of potential missing cases and the overestimation because of the ascertainment bias. CONCLUSION: The incidence of posttransplantation skin cancer is very low in Korean patients. However, the risk of skin cancer in organ transplant recipients may be considerably higher than that in the Korean general population.
Authors: Christina Lee Chung; Kumar S Nadhan; Christine M Shaver; Lauren M Ogrich; Mark Abdelmalek; Carrie Ann Cusack; Gregory E Malat; Ellen N Pritchett; Alden Doyle Journal: JAMA Dermatol Date: 2017-06-01 Impact factor: 10.282
Authors: Choon Chiat Oh; Haur Yueh Lee; Bien Keem Tan; Pryseley Nkouibert Assam; Terence Yi Shern Kee; Shiu Ming Pang Journal: Singapore Med J Date: 2018-10 Impact factor: 1.858