Nathan O'Callaghan1, Natalie Parletta2, Catherine M Milte2, Bianca Benassi-Evans3, Michael Fenech3, Peter R C Howe4. 1. Preventative Health Flagship, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, Australia. Electronic address: nathan.o'callaghan@csiro.au. 2. Nutritional Physiology Research Centre and Sansom Institute for Health Research, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia. 3. Preventative Health Flagship, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, Australia. 4. Nutritional Physiology Research Centre and Sansom Institute for Health Research, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia; Clinical Nutrition Research Centre, University of Newcastle, Callaghan, New South Wales, Australia.
Abstract
OBJECTIVES: Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI). METHODS:Thirty-three adults ages > 65 y with MCI were randomized to receive a supplement rich in the long-chain ω-3 PUFAs eicosapentaenoic acid (EPA; 1.67 g EPA + 0.16 g docosahexaenoic acid DHA/d; n = 12) or DHA (1.55 g DHA + 0.40 g EPA/d; n = 12), versus ω-6 PUFA linoleic acid (LA; 2.2 g/d; n = 9) for 6 mo. RESULTS: The intervention did not show an increase in telomere length with treatment and there was a trend toward telomere shortening during the intervention period. Linear mixed modeling produced a robust model although statistically underpowered. Telomere shortening was greatest in the LA group (d = 0.21) than in the DHA (d = 0.12) and EPA groups (d = 0.06). Increased erythrocyteDHA levels were associated with reduced telomere shortening (r = -0.67; P = 0.02) in the DHA group. CONCLUSION: Telomeric shortening may be attenuated by ω-3 PUFA supplementation, requiring further investigation in larger samples. Crown
RCT Entities:
OBJECTIVES: Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI). METHODS: Thirty-three adults ages > 65 y with MCI were randomized to receive a supplement rich in the long-chain ω-3 PUFAs eicosapentaenoic acid (EPA; 1.67 g EPA + 0.16 g docosahexaenoic acidDHA/d; n = 12) or DHA (1.55 g DHA + 0.40 g EPA/d; n = 12), versus ω-6 PUFA linoleic acid (LA; 2.2 g/d; n = 9) for 6 mo. RESULTS: The intervention did not show an increase in telomere length with treatment and there was a trend toward telomere shortening during the intervention period. Linear mixed modeling produced a robust model although statistically underpowered. Telomere shortening was greatest in the LA group (d = 0.21) than in the DHA (d = 0.12) and EPA groups (d = 0.06). Increased erythrocyte DHA levels were associated with reduced telomere shortening (r = -0.67; P = 0.02) in the DHA group. CONCLUSION: Telomeric shortening may be attenuated by ω-3 PUFA supplementation, requiring further investigation in larger samples. Crown
Authors: Hilary J Bethancourt; Mario Kratz; Shirley A A Beresford; M Geoffrey Hayes; Christopher W Kuzawa; Paulita L Duazo; Judith B Borja; Daniel T A Eisenberg Journal: Eur J Nutr Date: 2015-10-26 Impact factor: 5.614
Authors: Alison J Yeates; Sally W Thurston; Huiqi Li; Maria S Mulhern; Emeir M McSorley; Gene E Watson; Conrad F Shamlaye; J J Strain; Gary J Myers; Philip W Davidson; Edwin van Wijngaarden; Karin Broberg Journal: J Nutr Date: 2017-10-04 Impact factor: 4.798