| Literature DB >> 24342231 |
Michael R Pranzatelli1, Elizabeth D Tate2, Nathan R McGee2, Steven J Verhulst3.
Abstract
Using a panel of seven brain cell-specific biomarkers in cerebrospinal fluid (CSF), pediatric opsoclonus-myoclonus syndrome (OMS) (n=234) was compared to pediatric non-inflammatory neurological controls (n=84) and other inflammatory neurological disorders (OIND) (n=44). Only CSF NFL was elevated in untreated OMS versus controls (+83%). It was 87% higher in OIND than in OMS. On combination treatment with front-loaded ACTH, IVIg, rituximab, median CSF NFL decreased by 60% to control levels. These biochemical data suggest neuronal/axonal injury in some children with OMS without indicators of astrogliosis, and reduction on sufficient immunotherapy.Entities:
Keywords: ACTH; CSF; ELISA; GFAP; IVIg; NFL; NIND; NND; NSE; Neuroblastoma; Neurofilament pediatric ranges; OIND; Opsoclonus–myoclonus syndrome; Paraneoplastic syndrome; Pediatric neuroinflammation; S-100-beta protein; S100B; adrenocorticotropic hormone; cerebrospinal fluid; enzyme-linked immunosorbent assay; glia fibrillary acidic protein; intravenous immunoglobulins; neurofilament light chain protein or low molecular weight subunit; neuron specific enolase; non-inflammatory neurological disorders; non-inflammatory non-neurological disorders; other inflammatory neurological disorders; pNFH; phosphorylated neurofilament heavy chain protein or high molecular weight subunit
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Year: 2013 PMID： 24342231 DOI： 10.1016/j.jneuroim.2013.11.004
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478