AIMS: Several epidemiological studies have evaluated the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and brain tumour risk. However, results from these studies have been inconsistent. The aim of this detailed meta-analysis is to review and summarize the evidence on this association. METHODS: A comprehensive search for articles published up to September 2013 was performed. Studies evaluating the association between exposure to NSAIDs and risk of brain tumours were included. Random-effects meta-analytical models were used to calculate the relative risk (RR) and corresponding 95% confidence intervals (CIs). Sensitivity analyses, Galbraith plots and subgroup analyses were also performed. RESULTS: Ten studies (six case-control studies, three cohort studies and one randomized controlled trial), published between 2003 and 2013, were included in this analysis. Compared with non-use, overall use of NSAIDs was not statistically significantly associated with brain tumour risk based on the random-effects models (RR = 1.01; 95% CI = 0.89, 1.15). No differences were observed when analyses were stratified by gender and brain tumour subtype. Specific analysis for aspirin and non-aspirin NSAIDs yielded similar results. However, a slightly increased risk of brain tumour in NSAID users was observed in cohort studies (RR = 1.32; 95% CI = 1.06, 1.64; P = 0.014). Furthermore, our analysis did not show a significant association between frequency and dose of aspirin use and brain tumour risk. CONCLUSIONS: Use of NSAIDs (aspirin and non-aspirin NSAIDs) does not appear to be associated with brain tumour risk, but larger studies are needed to substantiate this relationship.
AIMS: Several epidemiological studies have evaluated the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and brain tumour risk. However, results from these studies have been inconsistent. The aim of this detailed meta-analysis is to review and summarize the evidence on this association. METHODS: A comprehensive search for articles published up to September 2013 was performed. Studies evaluating the association between exposure to NSAIDs and risk of brain tumours were included. Random-effects meta-analytical models were used to calculate the relative risk (RR) and corresponding 95% confidence intervals (CIs). Sensitivity analyses, Galbraith plots and subgroup analyses were also performed. RESULTS: Ten studies (six case-control studies, three cohort studies and one randomized controlled trial), published between 2003 and 2013, were included in this analysis. Compared with non-use, overall use of NSAIDs was not statistically significantly associated with brain tumour risk based on the random-effects models (RR = 1.01; 95% CI = 0.89, 1.15). No differences were observed when analyses were stratified by gender and brain tumour subtype. Specific analysis for aspirin and non-aspirin NSAIDs yielded similar results. However, a slightly increased risk of brain tumour in NSAID users was observed in cohort studies (RR = 1.32; 95% CI = 1.06, 1.64; P = 0.014). Furthermore, our analysis did not show a significant association between frequency and dose of aspirin use and brain tumour risk. CONCLUSIONS: Use of NSAIDs (aspirin and non-aspirin NSAIDs) does not appear to be associated with brain tumour risk, but larger studies are needed to substantiate this relationship.
Authors: Melissa L Bondy; Michael E Scheurer; Beatrice Malmer; Jill S Barnholtz-Sloan; Faith G Davis; Dora Il'yasova; Carol Kruchko; Bridget J McCarthy; Preetha Rajaraman; Judith A Schwartzbaum; Siegal Sadetzki; Brigitte Schlehofer; Tarik Tihan; Joseph L Wiemels; Margaret Wrensch; Patricia A Buffler Journal: Cancer Date: 2008-10-01 Impact factor: 6.860
Authors: Sarah E Daugherty; Steven C Moore; Ruth M Pfeiffer; Peter D Inskip; Yikyung Park; Albert Hollenbeck; Preetha Rajaraman Journal: Cancer Prev Res (Phila) Date: 2011-09-01
Authors: H T Sørensen; S Friis; B Nørgård; L Mellemkjaer; W J Blot; J K McLaughlin; A Ekbom; J A Baron Journal: Br J Cancer Date: 2003-06-02 Impact factor: 7.640
Authors: Smita Kumari; Sudhanshu Sharma; Dia Advani; Akanksha Khosla; Pravir Kumar; Rashmi K Ambasta Journal: Environ Sci Pollut Res Int Date: 2021-10-05 Impact factor: 5.190
Authors: E Susan Amirian; Quinn T Ostrom; Georgina N Armstrong; Rose K Lai; Xiangjun Gu; Daniel I Jacobs; Ali Jalali; Elizabeth B Claus; Jill S Barnholtz-Sloan; Dora Il'yasova; Joellen M Schildkraut; Francis Ali-Osman; Siegal Sadetzki; Robert B Jenkins; Daniel H Lachance; Sara H Olson; Jonine L Bernstein; Ryan T Merrell; Margaret R Wrensch; Christoffer Johansen; Richard S Houlston; Michael E Scheurer; Sanjay Shete; Christopher I Amos; Beatrice Melin; Melissa L Bondy Journal: Cancer Epidemiol Biomarkers Prev Date: 2018-11-27 Impact factor: 4.254
Authors: Corinna Seliger; Christoph R Meier; Claudia Becker; Susan S Jick; Ulrich Bogdahn; Peter Hau; Michael F Leitzmann Journal: PLoS One Date: 2016-02-12 Impact factor: 3.240
Authors: Xuesi Dong; Jieyu He; Lijuan Lin; Ying Zhu; Chao Chen; Li Su; Yang Zhao; Ruyang Zhang; Yongyue Wei; Feng Chen; David C Christiani Journal: Transl Lung Cancer Res Date: 2021-01