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Literature DB >> 24339387

Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.

Kyle K L Phua¹, David Boczkowski, Jens Dannull, Scott Pruitt, Kam W Leong, Smita K Nair.

Abstract

The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.

Entities: CellLine Chemical Disease Gene Species

Keywords: blood; cancer; immunotherapy; messenger RNA; vaccine

Mesh：

Substances：

Year: 2013 PMID： 24339387 PMCID： PMC4053491 DOI： 10.1002/adhm.201300512

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

30 in total

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15 in total

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Authors: Siddharth Patel; Avathamsa Athirasala; Paula P Menezes; N Ashwanikumar; Ting Zou; Gaurav Sahay; Luiz E Bertassoni
Journal: Tissue Eng Part A Date: 2018-06-07 Impact factor: 3.845

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Journal: J Control Release Date: 2022-01-10 Impact factor: 9.776

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4. Extracellular Vesicle-Mediated In Vitro Transcribed mRNA Delivery for Treatment of HER2⁺ Breast Cancer Xenografts in Mice by Prodrug CB1954 without General Toxicity.

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Journal: J Clin Invest Date: 2020-02-03 Impact factor: 14.808