BACKGROUND: Squamous cell carcinoma of the head and neck (SCCHN) usually emerges as a set of signs and symptoms that, either alone or in combination with standard treatment, may lead to malnutrition and weight loss. METHODS: This study evaluated patients with SCCHN before day 0 and 30 days after the end of treatment, with/without tumor resection. Each individual patient underwent analyses of body composition and resting metabolic rate, as well as assessment of serum glucose, insulin, leptin, adiponectin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1β, and insulin sensitivity. RESULTS: There was body mass loss during treatment and significant reduction in body fat and free fat mass. Early nutritional monitoring and tumor resection before treatment led to a better nutritional status and reduced inflammatory state. CONCLUSION: Early nutritional monitoring and resection of the tumor by surgery may be important factors for patients to better tolerate treatment.
BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) usually emerges as a set of signs and symptoms that, either alone or in combination with standard treatment, may lead to malnutrition and weight loss. METHODS: This study evaluated patients with SCCHN before day 0 and 30 days after the end of treatment, with/without tumor resection. Each individual patient underwent analyses of body composition and resting metabolic rate, as well as assessment of serum glucose, insulin, leptin, adiponectin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1β, and insulin sensitivity. RESULTS: There was body mass loss during treatment and significant reduction in body fat and free fat mass. Early nutritional monitoring and tumor resection before treatment led to a better nutritional status and reduced inflammatory state. CONCLUSION: Early nutritional monitoring and resection of the tumor by surgery may be important factors for patients to better tolerate treatment.
Authors: Teresa E Brown; Merrilyn D Banks; Brett G M Hughes; Charles Y Lin; Lizbeth M Kenny; Judith D Bauer Journal: Br J Cancer Date: 2017-05-23 Impact factor: 7.640
Authors: Eder C Pincinato; Ericka F D Costa; Leisa Lopes-Aguiar; Guilherme A S Nogueira; Tathiane R P Lima; Marília B Visacri; Anna P L Costa; Gustavo J Lourenço; Luciane Calonga; Fernanda V Mariano; Albina M A M Altemani; Cláudia Coutinho-Camillo; Carlos T Chone; Celso D Ramos; João M C Altemani; Patrícia Moriel; Carmen S P Lima Journal: Sci Rep Date: 2019-06-27 Impact factor: 4.379