| Literature DB >> 24339012 |
Mohammad B Haskali1, Peter D Roselt, John A Karas, Wayne Noonan, Christian W Wichmann, Andrew Katsifis, Rodney J Hicks, Craig A Hutton.
Abstract
The versatile (18) F-labeled prosthetic group, 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP), was synthesized in a single step in 45 min from 4-nitrophenyl 2-bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [(18) F]NFP, [(18) F]GalactoRGD - the current 'gold standard' tracer for imaging the expression of αV β3 integrin - was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [(18) F]fluoride.Entities:
Keywords: PET imaging; RGD peptide; [18F]fluoride; fluoropropionate; radiofluorination
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Year: 2013 PMID： 24339012 DOI： 10.1002/jlcr.3111
Source DB: PubMed Journal: J Labelled Comp Radiopharm ISSN： 0362-4803 Impact factor: 1.921